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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:6807
Term: methadone
Definition: A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
Chemical ID: MESH:D008691
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4decreases activityISOCYP2D6 (Homo sapiens)6480464CTDMethadone results in decreased activity of CYP2D6 proteinPMID:16595712
Cyp2d4increases metabolic processingISOCyp2d22 (Mus musculus)6480464CTDCYP2D22 protein results in increased metabolism of MethadonePMID:16595712
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