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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737013
Species: Homo sapiens
RGD Object: Gene
Symbol: TLR4
Name: toll like receptor 4
Acc ID: CHEBI:53063
Term: 2,4,6-trinitrobenzenesulfonic acid
Definition: The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D014302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TLR4decreases expressionISOTlr4 (Rattus norvegicus)6480464CTDTrinitrobenzenesulfonic Acid results in decreased expression of TLR4 mRNAPMID:19998380
TLR4increases expressionISOTlr4 (Rattus norvegicus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of TLR4; Trinitrobenzenesulfonic Acid results in increased expression of TLR4 proteinPMID:16891783 PMID:19002562
TLR4increases expressionISOTlr4 (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of TLR4; Trinitrobenzenesulfonic Acid results in increased expression of TLR4 proteinPMID:19597321 PMID:19956958 PMID:20136961
TLR4multiple interactionsISOTlr4 (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein]PMID:19002562
TLR4multiple interactionsISOTlr4 (Mus musculus)6480464CTDlancemaside A inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein]PMID:19956958
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