GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TNF | increases response to substance | EXP | | 6480464 | CTD | Wortmannin results in increased susceptibility to TNF protein | PMID:31445927 | TNF | multiple interactions | EXP | | 6480464 | CTD | Wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; Wortmannin inhibits the reaction [Dieldrin results in increased expression of TNF mRNA]; Wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] | PMID:12805067 PMID:16458614 PMID:16968468 PMID:22556157 PMID:25352548 PMID:31068361 | TNF | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | Wortmannin inhibits the reaction [4-hydroxyisoleucine inhibits the reaction [TNF protein results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] | PMID:12839867 PMID:17464197 PMID:22952890 PMID:26887316 | TNF | multiple interactions | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] | PMID:19810018 PMID:32805344 | | ||||||||||||||||||||||
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