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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:47575
Term: ABT-737
Definition: A biphenyl that is 4-chloro-1,1'-biphenyl substituted by a (4-{4-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene-1-sulfonyl)carbamoyl]phenyl}piperazin-1-yl)methyl group at position 2'. It is a BH3-mimetic drug which targets the anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins, including BCL-2, BCL-xL, and BCL-w, and induces apoptosis in cancer cells.
Chemical ID: MESH:C501332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases response to substanceISORGD:7331006480464CTDBCL2 protein modified form results in decreased susceptibility to ABT-737

PMID:17097560
Bcl2multiple interactionsISORGD:102306480464CTDABT-737 inhibits the reaction [BCL2 protein results in decreased susceptibility to Valproic Acid] ABT-737 inhibits the reaction [BCL2 protein results in decreased susceptibility to Vorinostat]

PMID:19060243
Bcl2multiple interactionsISORGD:7331006480464CTD[2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of BCL2 protein] which results in increased susceptibility to ABT-737 [ABT-737 inhibits the reaction [BCL2L11 protein binds to BCL2 protein]] promotes the reaction [BCL2L11 protein results in increased activity of BAX protein] [ABT-737 results in decreased activity of BCL2 protein] which results in increased susceptibility to fosbretabulin [BCL2L11 protein binds to BCL2 protein] which affects the susceptibility to ABT-737 ABT-737 inhibits the reaction [BAX protein binds to BCL2 protein] ABT-737 inhibits the reaction [BCL2L11 protein binds to BCL2 protein] ABT-737 inhibits the reaction [Silicon Dioxide promotes the reaction [BCL2 protein binds to BECN1 protein]] BCL2 protein inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]] BCL2 protein inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]

PMID:17097560 PMID:17200714 PMID:20104024 PMID:24321340 PMID:32061152
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