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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11440
Species: Mus musculus
RGD Object: Gene
Symbol: Trp53
Name: transformation related protein 53
Acc ID: CHEBI:46979
Term: N-acetylsphingosine
Definition: A N-acylsphingosine that has an acetamido group at position 2.
Chemical ID: MESH:C064769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trp53increases expressionISOTP53 (Homo sapiens)6480464CTDN-acetylsphingosine results in increased expression of TP53 mRNA; N-acetylsphingosine results in increased expression of TP53 proteinPMID:9535218
Trp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein]PMID:9535218
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