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ONTOLOGY REPORT - ANNOTATIONS


Term:N-acetylsphingosine
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Accession:CHEBI:46979 term browser browse the term
Definition:A N-acylsphingosine that has an acetamido group at position 2.
Synonyms:exact_synonym: N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]acetamide
 related_synonym: (2S,3R,4E)-2-(acetylamino)-4-octadecene-1,3-diol;   C2-ceramide;   Formula=C20H39NO3;   InChI=1S/C20H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h15-16,19-20,22,24H,3-14,17H2,1-2H3,(H,21,23)/b16-15+/t19-,20+/m0/s1;   InChIKey=BLTCBVOJNNKFKC-QUDYQQOWSA-N;   N-(acetyl)-sphing-4-enine;   N-[(2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]acetamide;   N-acetoyl-D-erythro-sphingosine;   N-acetyl-D-erythro-sphingosine;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO)NC(C)=O
 xref: CAS:3102-57-6 "ChemIDplus"
 xref_mesh: MESH:C064769
 xref: PMID:25656578 "Europe PMC";   PMID:27043542 "Europe PMC";   PMID:27807662 "Europe PMC";   PMID:28288862 "Europe PMC";   PMID:28572944 "Europe PMC";   Reaxys:1728870 "Reaxys"


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N-acetylsphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G Bcl2l1 BCL2-like 1 JBrowse link 2 152,758,732 152,833,803 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Cav1 caveolin 1, caveolae protein JBrowse link 6 17,306,335 17,341,328 RGD:6480464
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta JBrowse link 2 167,688,915 167,690,432 RGD:6480464
G Cftr cystic fibrosis transmembrane conductance regulator JBrowse link 6 18,170,687 18,322,770 RGD:6480464
G Clk1 CDC-like kinase 1 JBrowse link 1 58,411,988 58,424,088 RGD:6480464
G Ctsd cathepsin D JBrowse link 7 142,375,910 142,387,827 RGD:6480464
G Dapk1 death associated protein kinase 1 JBrowse link 13 60,601,723 60,763,191 RGD:6480464
G Dffb DNA fragmentation factor, beta subunit JBrowse link 4 153,964,447 153,975,121 RGD:6480464
G Dnm1l dynamin 1-like JBrowse link 16 16,312,228 16,359,038 RGD:6480464
G Egf epidermal growth factor JBrowse link 3 129,677,574 129,755,322 RGD:6480464
G F3 coagulation factor III JBrowse link 3 121,723,537 121,735,052 RGD:6480464
G Fis1 fission, mitochondrial 1 JBrowse link 5 136,953,275 136,966,234 RGD:6480464
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 7 25,228,258 25,237,851 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 16 38,089,001 38,246,084 RGD:6480464
G Gsta1 glutathione S-transferase, alpha 1 (Ya) JBrowse link 9 78,230,669 78,242,683 RGD:6480464
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) JBrowse link 9 78,331,018 78,347,192 RGD:6480464
G Gsta3 glutathione S-transferase, alpha 3 JBrowse link 1 21,240,565 21,265,575 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Hnf1a HNF1 homeobox A JBrowse link 5 114,948,980 114,971,062 RGD:6480464
G Id2 inhibitor of DNA binding 2 JBrowse link 12 25,093,799 25,096,092 RGD:6480464
G Il16 interleukin 16 JBrowse link 7 83,642,819 83,746,028 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Kdr kinase insert domain protein receptor JBrowse link 5 75,932,827 75,979,072 RGD:6480464
G Klf6 Kruppel-like factor 6 JBrowse link 13 5,861,489 5,870,393 RGD:6480464
G Lgals3 lectin, galactose binding, soluble 3 JBrowse link 14 47,373,860 47,386,167 RGD:6480464
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 10 19,934,101 20,142,750 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 11 49,846,728 49,886,421 RGD:6480464
G Mcl1 myeloid cell leukemia sequence 1 JBrowse link 3 95,656,944 95,663,179 RGD:6480464
G Mdm2 transformed mouse 3T3 cell double minute 2 JBrowse link 10 117,688,875 117,710,758 RGD:6480464
G Mfn2 mitofusin 2 JBrowse link 4 147,873,586 147,904,909 RGD:6480464
G Mir15b microRNA 15b JBrowse link 3 69,009,772 69,009,835 RGD:6480464
G Mir20a microRNA 20a JBrowse link 14 115,044,157 115,044,263 RGD:6480464
G Mir25 microRNA 25 JBrowse link 5 138,165,321 138,165,404 RGD:6480464
G Mir93 microRNA 93 JBrowse link 5 138,165,523 138,165,610 RGD:6480464
G Mirlet7b microRNA let7b JBrowse link 15 85,707,319 85,707,403 RGD:6480464
G Mirlet7d microRNA let7d JBrowse link 13 48,536,012 48,536,114 RGD:6480464
G Mirlet7e microRNA let7e JBrowse link 17 17,830,352 17,830,444 RGD:6480464
G Mirlet7i microRNA let7i JBrowse link 10 122,985,640 122,985,724 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Ngf nerve growth factor JBrowse link 3 102,469,919 102,521,013 RGD:6480464
G Nrp1 neuropilin 1 JBrowse link 8 128,358,591 128,505,476 RGD:6480464
G Nrp2 neuropilin 2 JBrowse link 1 62,703,317 62,818,692 RGD:6480464
G Odc1 ornithine decarboxylase, structural 1 JBrowse link 12 17,544,808 17,551,502 RGD:6480464
G Pink1 PTEN induced putative kinase 1 JBrowse link 4 138,313,409 138,326,296 RGD:6480464
G Plat plasminogen activator, tissue JBrowse link 8 22,757,722 22,782,848 RGD:6480464
G Plcg1 phospholipase C, gamma 1 JBrowse link 2 160,731,310 160,775,760 RGD:6480464
G Raf1 v-raf-leukemia viral oncogene 1 JBrowse link 6 115,618,569 115,676,635 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Rhob ras homolog family member B JBrowse link 12 8,497,661 8,500,009 RGD:6480464
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:6480464
G Sod2 superoxide dismutase 2, mitochondrial JBrowse link 17 13,007,839 13,018,119 RGD:6480464
G Sts steroid sulfatase RGD:6480464
G Tfe3 transcription factor E3 JBrowse link X 7,762,530 7,775,202 RGD:6480464
G Tgif1 TGFB-induced factor homeobox 1 JBrowse link 17 70,844,205 70,853,532 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 4 57,943,373 57,956,411 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 3 96,557,957 96,561,857 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21021
    role 21002
      biological role 21000
        biochemical role 19962
          metabolite 19889
            eukaryotic metabolite 19709
              animal metabolite 19425
                mammalian metabolite 19333
                  human metabolite 18799
                    N-acylsphingosine 77
                      N-acetylsphingosine 63
                        1-O-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl]-N-acetylsphingosine 0
                        1-O-arachidonoyl-N-acetylsphingosine 0
                        1-O-linoleoyl-N-acetylsphingosine 0
                        1-O-oleoyl-N-acetylsphingosine 0
                        1-O-palmitoyl-N-acetylsphingosine 0
                        1-O-stearoyl-N-acetylsphingosine 0
                        N-acetylsphingosine 1-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21021
    subatomic particle 21015
      composite particle 21015
        hadron 21015
          baryon 21015
            nucleon 21015
              atomic nucleus 21015
                atom 21015
                  main group element atom 20858
                    main group molecular entity 20858
                      s-block molecular entity 20348
                        hydrogen molecular entity 20256
                          hydrides 19087
                            inorganic hydride 17582
                              pnictogen hydride 17532
                                nitrogen hydride 17346
                                  azane 17217
                                    ammonia 17214
                                      organic amino compound 17213
                                        amino alcohol 875
                                          aminodiol 153
                                            2-aminooctadecene-1,3-diol 113
                                              2-aminooctadec-4-ene-1,3-diol 113
                                                sphing-4-enine 113
                                                  sphingosine 113
                                                    sphingosine-based sphingolipid 77
                                                      N-acylsphingosine 77
                                                        N-acetylsphingosine 63
                                                          1-O-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl]-N-acetylsphingosine 0
                                                          1-O-arachidonoyl-N-acetylsphingosine 0
                                                          1-O-linoleoyl-N-acetylsphingosine 0
                                                          1-O-oleoyl-N-acetylsphingosine 0
                                                          1-O-palmitoyl-N-acetylsphingosine 0
                                                          1-O-stearoyl-N-acetylsphingosine 0
                                                          N-acetylsphingosine 1-phosphate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.