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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553513
Species: Mus musculus
RGD Object: Gene
Symbol: Tlr3
Name: toll-like receptor 3
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr3increases expressionEXP 6480464CTDAcetaminophen results in increased expression of TLR3 proteinPMID:26079055
Tlr3multiple interactionsEXP 6480464CTDChlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein]PMID:26079055
Tlr3decreases expressionISOTLR3 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of TLR3 mRNAPMID:21420995 PMID:27761495 PMID:29067470
Tlr3decreases expressionISOTlr3 (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of TLR3 mRNAPMID:33387578
Tlr3multiple interactionsISOTLR3 (Homo sapiens)6480464CTD[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in increased expression of TLR3 mRNAPMID:33819548
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