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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737111
Species: Homo sapiens
RGD Object: Gene
Symbol: EGR1
Name: early growth response 1
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGR1decreases expressionISOEgr1 (Rattus norvegicus)6480464CTDClofibrate results in decreased expression of EGR1 mRNAPMID:15033592
EGR1increases expressionISOEgr1 (Mus musculus)6480464CTDClofibrate analog results in increased expression of EGR1 mRNAPMID:8764118
EGR1increases expressionISOEgr1 (Rattus norvegicus)6480464CTDClofibrate results in increased expression of EGR1 mRNAPMID:15585944
EGR1multiple interactionsISOEgr1 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of EGR1 mRNA; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EGR1 mRNA]PMID:17585979
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