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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621396
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rpe65
Name: retinoid isomerohydrolase RPE65
Acc ID: CHEBI:35154
Term: manganese(0)
Definition: An elemental manganese that has formula Mn.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rpe65decreases uptakeISORpe65 (Mus musculus)6480464CTDRPE65 exon mutant form results in decreased uptake of ManganesePMID:19060264
Rpe65increases uptakeISORpe65 (Mus musculus)6480464CTDRPE65 protein results in increased uptake of ManganesePMID:19060264
Rpe65multiple interactionsISORpe65 (Mus musculus)6480464CTD[retinylamine results in decreased activity of RPE65 protein] which results in decreased uptake of Manganese; Retinaldehyde inhibits the reaction [RPE65 exon mutant form results in decreased uptake of Manganese]PMID:19060264
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