manganese(0) - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	manganese(0)	go back to main search page
Accession:	CHEBI:35154	browse the term
Definition:	An elemental manganese that has formula Mn.
Synonyms:	related_synonym:	Formula=Mn; InChI=1S/Mn; InChIKey=PWHULOQIROXLJO-UHFFFAOYSA-N; Mn(0); Mnn; SMILES=[Mn]; colloidal manganese; manganese
	xref:	CAS:7439-96-5
	xref_mesh:	MESH:D008345

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Genes (441)

manganese(0)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 5

decreases expression

Manganese results in decreased expression of ABCA5 mRNA

NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976

G

ATP binding cassette subfamily A member 9

increases expression

Manganese results in increased expression of ABCA9 mRNA

NCBI chr10:95,077,615...95,137,751
Ensembl chr10:95,079,058...95,139,608

G

ATP binding cassette subfamily B member 1A

increases activity
multiple interactions
increases expression

Manganese results in increased activity of ABCB1 protein
[Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate
Manganese results in increased expression of ABCB1A mRNA

PMID:2900677 PMID:26745496

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 6

multiple interactions

Manganese promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]; Manganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily C member 8

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of ABCC8 protein

NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510

G

abl-interactor 2

increases expression

Manganese results in increased expression of ABI2 mRNA

NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:61,827,139...61,905,699

G

acetyl-CoA acetyltransferase 2

decreases expression

Manganese results in decreased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

acetylcholinesterase

multiple interactions
increases activity

[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of ACHE protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein]; Taurine inhibits the reaction [Manganese results in increased activity of ACHE protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of ACHE mRNA alternative form

PMID:24885898 PMID:30738988 PMID:30844427 PMID:32445656 PMID:33314588 More...

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

aconitase 1

decreases activity
increases activity
multiple interactions

Manganese results in decreased activity of ACO1 protein
Manganese results in increased activity of ACO1 protein
Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]

PMID:16386771 PMID:16545456 PMID:16568477 PMID:16729984 PMID:17469137

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

multiple interactions
decreases activity
decreases expression

ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Manganese results in decreased expression of ACO2 mRNA; Manganese results in decreased expression of ACO2 protein
Iron inhibits the reaction [Manganese results in decreased activity of ACO2 protein]

PMID:9675333 PMID:16625280 PMID:17469137

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

actin, alpha 1, skeletal muscle

decreases expression

Manganese results in decreased expression of ACTA1 mRNA

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin related protein 3

affects expression

Manganese affects the expression of ACTR3 protein

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

adhesion G protein-coupled receptor E1

increases expression

Manganese results in increased expression of ADGRE1 mRNA

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

G

adrenomedullin

increases expression

Manganese results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

alpha-fetoprotein

decreases expression

Manganese results in decreased expression of AFP mRNA

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

A-kinase anchoring protein 7

decreases expression

Manganese results in decreased expression of AKAP7 mRNA

NCBI chr 1:20,087,190...20,217,799
Ensembl chr 1:20,087,373...20,217,797

G

AKT serine/threonine kinase 1

decreases expression
increases phosphorylation
multiple interactions

Manganese results in decreased expression of AKT1 protein
Manganese results in increased phosphorylation of AKT1 protein
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]

PMID:17043766 PMID:24845367 PMID:31676349

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

[Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

angiopoietin 2

decreases expression

Manganese results in decreased expression of ANGPT2 mRNA

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

angiopoietin-like 4

increases expression

Manganese results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

acidic nuclear phosphoprotein 32 family member A

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of ANP32A mRNA

NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443

G

adaptor related protein complex 3 subunit beta 2

increases expression

Manganese results in increased expression of AP3B2 mRNA

NCBI chr 1:135,412,580...135,445,191
Ensembl chr 1:135,412,580...135,445,191

G

apolipoprotein L2

increases expression

Manganese results in increased expression of APOL2 mRNA

NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558

G

amyloid beta precursor protein

increases expression

Manganese results in increased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 4

multiple interactions

Antioxidants inhibits the reaction [Manganese results in increased expression of AQP4 protein]

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

arginase 1

affects binding
multiple interactions

Manganese binds to ARG1 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of ARG1 mRNA

PMID:15248756 PMID:18802628 PMID:34018660

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Rho GDP dissociation inhibitor alpha

decreases expression

Manganese results in decreased expression of ARHGDIA mRNA

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

Rho guanine nucleotide exchange factor 4

increases expression

Manganese results in increased expression of ARHGEF4 mRNA

NCBI chr 9:36,861,800...37,005,079
Ensembl chr 9:36,861,835...37,005,075

G

activating transcription factor 1

increases phosphorylation
multiple interactions

Manganese results in increased phosphorylation of ATF1 protein
SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of ATF1 protein]

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

activating transcription factor 6

decreases expression

Manganese results in decreased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ATM serine/threonine kinase

decreases expression

Manganese results in decreased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

atonal bHLH transcription factor 8

decreases expression

Manganese results in decreased expression of ATOH8 mRNA

NCBI chr 4:104,259,992...104,292,168
Ensembl chr 4:104,259,992...104,292,168

G

ATPase cation transporting 13A2

affects response to substance
decreases response to substance

ATP13A2 gene polymorphism affects the susceptibility to Manganese
ATP13A2 protein results in decreased susceptibility to Manganese

PMID:22285144 PMID:22847264 PMID:25461191

NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139

G

ATPase Na+/K+ transporting subunit alpha 3

decreases expression
increases methylation

Manganese results in decreased expression of ATP1A3 mRNA
Manganese results in increased methylation of ATP1A3 promoter

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

G

ATPase H+ transporting V1 subunit H

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of ATP6V1H mRNA; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of ATP6V1H mRNA]

NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962

G

ATPase copper transporting alpha

affects localization
decreases expression

Manganese affects the localization of ATP7A protein
Manganese results in decreased expression of ATP7A mRNA; Manganese results in decreased expression of ATP7A protein

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

ATPase copper transporting beta

increases phosphorylation
affects localization
decreases expression

Manganese results in increased phosphorylation of ATP7B protein
Manganese affects the localization of ATP7B protein
Manganese results in decreased expression of ATP7B mRNA; Manganese results in decreased expression of ATP7B protein

PMID:19405516 PMID:24614235

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

ATPase phospholipid transporting 8A1

decreases expression

Manganese results in decreased expression of ATP8A1 mRNA

NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611

G

beta-secretase 1

increases expression

Manganese results in increased expression of BACE1 mRNA

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; [Manganese co-treated with NGF protein] results in increased expression of BAX protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; Rolipram inhibits the reaction [Manganese results in increased expression of BAX protein]
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]
[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]

PMID:25027559 PMID:25791630 PMID:29115570 PMID:30844427 PMID:30951808 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in decreased expression of BCL2 mRNA; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of BCL2 protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; [Streptozocin co-treated with Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in decreased expression of BCL2 mRNA; [Streptozocin co-treated with Manganese] results in decreased expression of BCL2 mRNA; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein]; Rolipram inhibits the reaction [Manganese results in decreased expression of BCL2 protein]
Manganese results in decreased expression of BCL2 mRNA; Manganese results in decreased expression of BCL2 protein

PMID:30844427 PMID:30951808 PMID:31161640 PMID:31676349 PMID:32246071 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression
multiple interactions

Manganese results in decreased expression of BCL2L1 protein
[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

brain-derived neurotrophic factor

multiple interactions
decreases expression

[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; Rolipram inhibits the reaction [Manganese results in decreased expression of BDNF protein]
Manganese results in decreased expression of BDNF mRNA; Manganese results in decreased expression of BDNF protein

PMID:17827730 PMID:25099302 PMID:29205667 PMID:30951808 PMID:31161640 More...

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

BCL2 interacting protein 3

multiple interactions

Antioxidants inhibits the reaction [Manganese results in increased expression of BNIP3 protein]

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

Manganese results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

calcium binding and coiled-coil domain 2

increases expression

Manganese results in increased expression of CALCOCO2 mRNA

NCBI chr10:81,055,467...81,069,298

G

calreticulin

affects expression

Manganese affects the expression of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calcium/calmodulin-dependent protein kinase II alpha

decreases phosphorylation

Manganese results in decreased phosphorylation of CAMK2A protein

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calpain 1

increases activity
multiple interactions

Manganese results in increased activity of CAPN1 protein
calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein]

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

carbonic anhydrase 8

increases expression

Manganese results in increased expression of CAR8 mRNA

NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374

G

caspase 3

multiple interactions
increases cleavage
increases expression
increases activity

[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of CASP3 protein; [Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in increased expression of CASP3 mRNA; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of CASP3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein; [Streptozocin co-treated with Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in increased expression of CASP3 mRNA; [Streptozocin co-treated with Manganese] results in increased expression of CASP3 mRNA; aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Deferoxamine inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein]; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]; Manganese results in increased expression of and results in increased cleavage of CASP3 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Manganese results in increased activity of CASP3 protein]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 mRNA]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 protein]
Manganese results in increased expression of CASP3 mRNA; Manganese results in increased expression of CASP3 protein
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein]; SNCA protein inhibits the reaction [Manganese results in increased activity of CASP3 protein]

PMID:11933051 PMID:16787641 PMID:21985864 PMID:22427945 PMID:22841634 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity

Manganese results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases activity
multiple interactions

Manganese results in increased activity of CASP8 protein
Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases cleavage
multiple interactions
increases activity

Manganese results in increased cleavage of CASP9 protein
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein]; SNCA protein inhibits the reaction [Manganese results in increased activity of CASP9 protein]

PMID:16787641 PMID:25416158 PMID:29115570

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity

[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased activity of CAT protein; [Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased activity of CAT protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Manganese results in decreased activity of CAT protein]

PMID:16595185 PMID:17176674 PMID:23339144 PMID:25817889 PMID:30844427 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

decreases expression

Manganese results in decreased expression of CAV1 mRNA; Manganese results in decreased expression of CAV1 protein

PMID:23499988 PMID:23597857

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

caveolin 3

decreases expression

Manganese results in decreased expression of CAV3 mRNA; Manganese results in decreased expression of CAV3 protein

NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137

G

C-C motif chemokine ligand 2

increases expression

Manganese results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 7

increases expression

Manganese results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cyclin A1

increases expression

Manganese results in increased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin B1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

decreases expression
multiple interactions

Manganese results in decreased expression of CCNB2 mRNA
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA]; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein]

PMID:17175027 PMID:34822792

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

increases expression

Manganese results in increased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

Cd48 molecule

increases expression

Manganese results in increased expression of CD48 mRNA

NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142

G

CD8 subunit beta

increases expression

Manganese results in increased expression of CD8B mRNA; Manganese results in increased expression of CD8B1 mRNA

NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553

G

cyclin-dependent kinase inhibitor 2C

decreases expression

Manganese results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

cyclin-dependent kinase inhibitor 3

decreases expression

Manganese results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

CCAAT/enhancer binding protein delta

increases expression

Manganese results in increased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

cadherin, EGF LAG seven-pass G-type receptor 1

increases expression

Manganese results in increased expression of CELSR1 mRNA

NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164

G

centrosomal protein 128

decreases expression

Manganese results in decreased expression of CEP128 mRNA

NCBI chr 6:109,951,009...110,328,686
Ensembl chr 6:109,951,061...110,328,713

G

choline O-acetyltransferase

decreases activity
multiple interactions

Manganese results in decreased activity of CHAT protein
Taurine inhibits the reaction [Manganese results in decreased activity of CHAT protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CHAT protein

PMID:24885898 PMID:30738988

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

chromodomain helicase DNA binding protein 7

increases expression
decreases methylation

Manganese results in increased expression of CHD7 mRNA
Manganese results in decreased methylation of CHD7 gene

NCBI chr 5:21,812,007...21,995,358
Ensembl chr 5:21,812,070...21,995,358

G

charged multivesicular body protein 4B

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of CHMP4B protein

NCBI chr 3:143,170,859...143,211,376
Ensembl chr 3:143,170,902...143,210,844

G

CDC28 protein kinase regulatory subunit 2

decreases expression

Manganese results in decreased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

claudin 23

increases expression

Manganese results in increased expression of CLDN23 mRNA

NCBI chr16:56,413,677...56,415,401
Ensembl chr16:56,413,381...56,415,523

G

claudin domain containing 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CLDND1 mRNA

NCBI chr11:41,883,120...41,889,471
Ensembl chr11:41,883,134...41,889,354

G

CLN6, transmembrane ER protein

increases abundance

CLN6 gene mutant form results in increased abundance of Manganese

NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360

G

CCR4-NOT transcription complex, subunit 2

decreases expression

Manganese results in decreased expression of CNOT2 mRNA

NCBI chr 7:52,130,445...52,222,338
Ensembl chr 7:52,130,441...52,223,575

G

CCR4-NOT transcription complex, subunit 6-like

increases expression

Manganese results in increased expression of CNOT6L mRNA

NCBI chr14:13,410,499...13,502,511
Ensembl chr14:13,411,281...13,498,203

G

collagen type XII alpha 1 chain

decreases expression

Manganese results in decreased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

G

carboxypeptidase M

decreases expression

Manganese results in decreased expression of CPM mRNA

NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220

G

cAMP responsive element binding protein 1

increases phosphorylation
multiple interactions
decreases expression
decreases phosphorylation

Manganese results in increased phosphorylation of CREB1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; Rolipram inhibits the reaction [Manganese results in decreased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of CREB1 protein]
Manganese results in decreased expression of CREB1 mRNA; Manganese results in decreased expression of CREB1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CREB1 protein; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]

PMID:16787641 PMID:29205667 PMID:30951808 PMID:31161640 PMID:31676349 More...

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

corticotropin releasing hormone

multiple interactions

CRH protein inhibits the reaction [Manganese results in increased chemical synthesis of Cyclic AMP]

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

crystallin, mu

affects expression

Manganese affects the expression of CRYM protein

NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633

G

cysteine and glycine rich protein 3

increases expression

Manganese results in increased expression of CSRP3 mRNA

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

catenin alpha 1

decreases expression

Manganese results in decreased expression of CTNNA1 mRNA

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin beta 1

decreases expression

Manganese results in decreased expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

C-X-C motif chemokine ligand 12

decreases expression

Manganese results in decreased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 14

increases expression

Manganese results in increased expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 2

increases expression

Manganese results in increased expression of CXCL2 mRNA

PMID:17175027 PMID:19782702 PMID:20224926

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 6

increases expression

Manganese results in increased expression of CXCL6 mRNA

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

cytochrome c, somatic

multiple interactions
affects localization

SNCA protein inhibits the reaction [Manganese affects the localization of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

Manganese results in decreased expression of CYP11A1 protein

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 26, subfamily b, polypeptide 1

decreases expression

Manganese results in decreased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases response to substance

CYP2D6 gene polymorphism results in decreased susceptibility to Manganese

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions
increases activity

[Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Manganese results in increased activity of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

dachshund family transcription factor 2

increases expression

Manganese results in increased expression of DACH2 mRNA

NCBI chr X:78,718,963...79,018,023
Ensembl chr X:78,451,593...79,017,592

G

dynactin subunit 3

affects expression

Manganese affects the expression of DCTN3 protein

NCBI chr 5:56,881,085...56,889,041
Ensembl chr 5:56,881,085...56,889,102

G

dimethylarginine dimethylaminohydrolase 1

decreases expression
multiple interactions

Manganese deficiency results in decreased expression of DDAH1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of DDAH1 protein]

NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

Manganese results in increased expression of DDIT3 protein
Manganese results in increased expression of DDIT3 mRNA
[manganese chloride results in increased abundance of Manganese] which results in increased expression of DDIT3 mRNA

PMID:21477646 PMID:23499988 PMID:32574669

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dihydrolipoamide dehydrogenase

decreases expression

Manganese results in decreased expression of DLD protein

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

dynein axonemal heavy chain 14

decreases expression

Manganese results in decreased expression of DNAH14 mRNA

NCBI chr13:93,322,653...93,540,706
Ensembl chr13:93,322,711...93,538,646

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

Manganese results in decreased expression of DNPH1 mRNA

NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022

G

dipeptidylpeptidase 4

increases expression

Manganese results in increased expression of DPP4 mRNA

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

down-regulator of transcription 1

decreases expression

Manganese results in decreased expression of DR1 mRNA

NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638

G

dopamine receptor D2

decreases expression
affects expression

Manganese results in decreased expression of DRD2 mRNA
Manganese affects the expression of DRD2 protein

PMID:20224926 PMID:33881537

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

DS cell adhesion molecule-like 1

increases expression

Manganese results in increased expression of DSCAML1 mRNA

NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320

G

dentin sialophosphoprotein

increases expression

Manganese results in increased expression of DSPP mRNA

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

G

dual specificity phosphatase 1

multiple interactions
decreases expression

[Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 mRNA; [Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 protein
Manganese results in decreased expression of DUSP1 mRNA; Manganese results in decreased expression of DUSP1 protein

NCBI chr10:16,680,478...16,683,275

G

eukaryotic translation initiation factor 2A

increases expression

Manganese results in increased expression of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2-alpha kinase 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

E74 like ETS transcription factor 1

decreases expression

Manganese results in decreased expression of ELF1 mRNA

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

G

EMAP like 2

increases expression

Manganese results in increased expression of EML2 mRNA

NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341

G

enolase 1

decreases activity

Manganese results in decreased activity of ENO1 protein

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

erythropoietin

increases glycosylation

Manganese results in increased glycosylation of EPO protein

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

decreases expression

Manganese results in decreased expression of ERCC6L mRNA

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

epiregulin

increases expression

Manganese results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

glutamate-rich 1

increases expression

Manganese results in increased expression of ERICH1 mRNA

NCBI chr16:75,501,322...75,569,129
Ensembl chr16:75,501,384...75,569,128

G

estrogen receptor 1

increases expression

Manganese results in increased expression of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

exocyst complex component 6

decreases expression

Manganese results in decreased expression of EXOC6 mRNA

NCBI chr 1:235,314,612...235,457,824
Ensembl chr 1:235,300,369...235,457,015

G

EYA transcriptional coactivator and phosphatase 4

decreases expression

Manganese results in decreased expression of EYA4 mRNA

NCBI chr 1:22,172,275...22,415,978
Ensembl chr 1:22,172,275...22,415,976

G

coagulation factor II, thrombin

multiple interactions
increases uptake

1-Methyl-3-isobutylxanthine inhibits the reaction [F2 protein results in increased uptake of Manganese]; Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese]; Nickel inhibits the reaction [F2 protein results in increased uptake of Manganese]; Tetradecanoylphorbol Acetate inhibits the reaction [F2 protein results in increased uptake of Manganese]

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fatty acid 2-hydroxylase

increases expression

Manganese results in increased expression of FA2H mRNA

NCBI chr19:39,312,904...39,364,153
Ensembl chr19:39,312,906...39,364,153

G

family with sequence similarity 107, member A

decreases expression

Manganese results in decreased expression of FAM107A mRNA

NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396

G

family with sequence similarity 180, member A

decreases expression

Manganese results in decreased expression of FAM180A mRNA

NCBI chr 4:63,992,867...64,008,047
Ensembl chr 4:63,992,867...64,008,047

G

FA complementation group F

decreases expression

Manganese results in decreased expression of FANCF mRNA

NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923

G

Fc gamma receptor 1A

decreases expression

Manganese results in decreased expression of FCGR1A mRNA

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

G

fibroblast growth factor binding protein 1

decreases expression

Manganese results in decreased expression of FGFBP1 mRNA

NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496

G

four and a half LIM domains 1

decreases expression

Manganese results in decreased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

fin bud initiation factor homolog

increases expression

Manganese results in increased expression of FIBIN mRNA

NCBI chr 3:96,942,405...96,944,676
Ensembl chr 3:96,942,406...96,944,676

G

folliculin

increases expression

Manganese results in increased expression of FLCN mRNA

NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Manganese results in decreased expression of FOS protein
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein]

PMID:17043766 PMID:17827730 PMID:22561169

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box N4

increases expression

Manganese results in increased expression of FOXN4 mRNA

NCBI chr12:42,336,706...42,359,932
Ensembl chr12:42,340,323...42,359,921

G

forkhead box O3

multiple interactions
affects localization

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese affects the localization of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese results in increased expression of FOXO3 protein]; Manganese results in increased expression of and results in increased phosphorylation of FOXO3 protein; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box P2

increases expression

Manganese results in increased expression of FOXP2 mRNA

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

ferritin heavy chain 1

decreases expression
increases expression

Manganese results in decreased expression of FTH1 mRNA; Manganese results in decreased expression of FTH1 protein
Manganese results in increased expression of FTH1 protein

PMID:16545456 PMID:16568477 PMID:16740617 PMID:17469137

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

FXYD domain-containing ion transport regulator 2

increases expression

Manganese results in increased expression of FXYD2 mRNA

NCBI chr 8:45,712,901...45,720,032
Ensembl chr 8:45,712,903...45,720,203

G

gamma-aminobutyric acid type B receptor subunit 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of GABBR2 protein

NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of GABRA1 protein

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit gamma 2

increases expression

Manganese results in increased expression of GABRG2 mRNA

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Manganese results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

galanin and GMAP prepropeptide

increases expression

Manganese results in increased expression of GAL mRNA

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

GC-rich sequence DNA-binding factor 2

decreases expression

Manganese results in decreased expression of GCFC2 mRNA

NCBI chr 4:114,481,613...114,519,268
Ensembl chr 4:114,481,607...114,519,962

G

ganglioside-induced differentiation-associated-protein 2

increases expression

Manganese results in increased expression of GDAP2 mRNA

NCBI chr 2:187,528,514...187,585,270
Ensembl chr 2:187,528,513...187,585,270

G

growth differentiation factor 15

increases expression

Manganese results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glial fibrillary acidic protein

decreases expression
increases expression
affects expression

Manganese results in decreased expression of GFAP mRNA
Manganese results in increased expression of GFAP mRNA; Manganese results in increased expression of GFAP protein
Manganese affects the expression of GFAP protein

PMID:19782702 PMID:20224926 PMID:23832297 PMID:24885898

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gamma-glutamyltransferase 1

multiple interactions

[Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of GGT1 protein

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

gap junction protein, alpha 5

decreases expression

Manganese results in decreased expression of GJA5 mRNA

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

G

gliomedin

decreases expression

Manganese results in decreased expression of GLDN mRNA

NCBI chr 8:54,679,015...54,723,198
Ensembl chr 8:54,679,119...54,723,196

G

glutamate dehydrogenase 1

decreases expression
multiple interactions

Manganese deficiency results in decreased expression of GLUD1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of GLUD1 protein]

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

glutamate-ammonia ligase

affects expression
decreases expression

Manganese affects the expression of GLUL mRNA; Manganese affects the expression of GLUL protein
Manganese results in decreased expression of GLUL mRNA; Manganese results in decreased expression of GLUL protein

PMID:16842851 PMID:16943606

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

gonadotropin releasing hormone 1

increases expression

Manganese results in increased expression of GNRH1 mRNA

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

G protein-coupled estrogen receptor 1

multiple interactions

[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in decreased susceptibility to Manganese

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

G protein-coupled receptor 18

decreases expression

Manganese results in decreased expression of GPR18 mRNA

NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470

G

G protein-coupled receptor 34

decreases expression

Manganese results in decreased expression of GPR34 mRNA

NCBI chr X:9,104,829...9,113,796
Ensembl chr X:9,104,565...9,148,601

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression

Manganese results in decreased expression of GRIN1 mRNA; Manganese results in decreased expression of GRIN1 protein

PMID:19643132 PMID:29205667

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

Manganese results in decreased expression of GRIN2A mRNA; Manganese results in decreased expression of GRIN2A protein

PMID:19643132 PMID:29205667

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

Manganese results in decreased expression of GRIN2B mRNA; Manganese results in decreased expression of GRIN2B protein

PMID:19643132 PMID:29205667

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glutathione-disulfide reductase

decreases expression
multiple interactions

Manganese results in decreased expression of GSR mRNA
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of GSR protein

PMID:17175027 PMID:17176674 PMID:32445656

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase pi 1

affects response to substance

GSTP1 gene polymorphism affects the susceptibility to Manganese

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

general transcription factor IIH subunit 1

decreases expression

Manganese results in decreased expression of GTF2H1 mRNA

NCBI chr 1:97,321,417...97,349,455
Ensembl chr 1:97,321,394...97,349,455

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

G

hepcidin antimicrobial peptide

decreases expression
multiple interactions

Manganese results in decreased expression of HAMP mRNA
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of HAMP protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of HAMP protein

PMID:29020610 PMID:34590183

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

histone deacetylase 1

multiple interactions

Manganese promotes the reaction [RELA protein binds to HDAC1 protein]; Manganese promotes the reaction [YY1 protein binds to HDAC1 protein]
[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]

PMID:24469401 PMID:34800614

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 3

multiple interactions

[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]]

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

G

hephaestin

increases expression

Manganese results in increased expression of HEPH mRNA

NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980

G

hexosaminidase D

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of HEXD mRNA

NCBI chr10:106,479,781...106,498,799
Ensembl chr10:106,480,194...106,498,799

G

homeostatic iron regulator

affects abundance

HFE protein affects the abundance of Manganese

NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

Manganese results in increased expression of and results in increased activity of HIF1A protein
Manganese results in increased expression of HIF1A mRNA
[[manganese chloride results in increased abundance of Manganese] which co-treated with Ethanol] results in increased expression of HIF1A protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of HIF1A protein

PMID:16386771 PMID:17175027 PMID:34590183

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hypoxia inducible factor 1 subunit alpha inhibitor

decreases expression

Manganese results in decreased expression of HIF1AN mRNA

NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
increases activity

[Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein
Manganese results in increased activity of HMGCR protein

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

Manganese results in decreased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heme oxygenase 1

increases expression
multiple interactions

Manganese results in increased expression of HMOX1 mRNA
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein]

PMID:11181820 PMID:18948096 PMID:23832297 PMID:32574669

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

homeo box B9

decreases expression

Manganese results in decreased expression of HOXB9 mRNA

NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Manganese results in increased expression of HSPA5 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HSPA5 mRNA

PMID:21477646 PMID:32574669

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

multiple interactions

[Manganese binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in increased expression of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

5-hydroxytryptamine receptor 1A

multiple interactions

Manganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

huntingtin

decreases uptake
decreases abundance
decreases response to substance
multiple interactions

HTT protein mutant form results in decreased uptake of Manganese
HTT gene mutant form results in decreased abundance of Manganese
HTT gene mutant form results in decreased susceptibility to Manganese
HTT protein mutant form inhibits the reaction [Manganese results in decreased expression of UBQLN1 protein]; HTT protein mutant form inhibits the reaction [Manganese results in increased expression of NEFL protein]; Manganese inhibits the reaction [HTT protein mutant form affects the expression of SAE1 protein]
Manganese results in decreased phosphorylation of and results in increased expression of HTT protein

PMID:19845833 PMID:20547568 PMID:22191580 PMID:25099302

NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070

G

inhibitor of DNA binding 2

increases expression

Manganese results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

affects binding

Manganese binds to IDH3A protein

NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

affects binding
multiple interactions

Manganese binds to IDH3G protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of IDH3G mRNA

PMID:16737955 PMID:35690225

NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171

G

interferon gamma

multiple interactions

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Free Radicals]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; [Lipopolysaccharides co-treated with IFNG protein co-treated with Manganese] results in decreased abundance of Nitric Oxide; [pyrazolanthrone co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; [SB 203580 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; [U 0126 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Free Radicals]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]
Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]

PMID:16168523 PMID:16488514

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

IKBKB gene mutant form results in increased susceptibility to [manganese chloride results in increased abundance of Manganese]
[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]; IkK-16 compound inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]

PMID:32692843 PMID:34310962

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 12A

increases expression

Manganese results in increased expression of IL12A mRNA

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 1 beta

increases expression
multiple interactions

Manganese results in increased expression of IL1B mRNA
[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein]
[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein

PMID:19782702 PMID:33314588 PMID:34018660

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

decreases expression

Manganese results in decreased expression of IL1RL1 mRNA

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 2

multiple interactions

Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 protein]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL4 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases expression
multiple interactions
increases secretion
increases uptake

Manganese results in increased expression of IL6 mRNA; Manganese results in increased expression of IL6 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL6 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL6 protein; [Manganese co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA
Manganese results in increased secretion of IL6 protein
[IL6 protein results in decreased expression of SLC30A10 mRNA] which results in decreased export of Manganese; [IL6 protein results in decreased expression of SLC30A10 protein] which results in decreased export of Manganese
IL6 protein results in increased uptake of Manganese
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of IL6 protein

PMID:17065364 PMID:19263519 PMID:20224926 PMID:20589745 PMID:24576911 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 7

increases expression

Manganese results in increased expression of IL7 mRNA

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

G

insulin 1

multiple interactions

[Manganese co-treated with INS1 protein] results in increased phosphorylation of INSR protein; [Manganese co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein; Manganese deficiency inhibits the reaction [INS1 protein results in increased oxidation of Glucose]; Manganese deficiency inhibits the reaction [INS1 protein results in increased uptake of 3-O-Methylglucose]

PMID:1321133 PMID:2204694

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] inhibits the reaction [Glucose results in increased secretion of INS protein]; [Manganese co-treated with Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein]

PMID:2542339 PMID:31555879

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

insulin receptor

multiple interactions
decreases expression

[Manganese co-treated with INS1 protein] results in increased phosphorylation of INSR protein
[Manganese co-treated with Magnesium co-treated with INS protein] results in increased phosphorylation of and results in increased activity of INSR protein; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein modified form]; [Polylysine co-treated with Manganese co-treated with Magnesium] promotes the reaction [INS protein results in increased phosphorylation of and results in increased activity of INSR protein]
Manganese deficiency results in decreased expression of INSR protein

PMID:1321133 PMID:2204694 PMID:2542339

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

iron responsive element binding protein 2

decreases activity
increases expression

Manganese results in decreased activity of IREB2 protein
Manganese results in increased expression of IREB2 protein

PMID:16568477 PMID:17469137

NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611

G

insulin receptor substrate 4

multiple interactions

[Manganese co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein

NCBI chr X:105,344,020...105,360,004

G

integrin subunit alpha 3

increases expression

Manganese results in increased expression of ITGA3 mRNA

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit alpha M

increases expression

Manganese results in increased expression of ITGAM mRNA

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 1

increases activity

Manganese results in increased activity of ITGB1 protein

PMID:10820171 PMID:16606368

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 5

increases expression

Manganese results in increased expression of ITGB5 mRNA

NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472

G

inter-alpha trypsin inhibitor, heavy chain 1

multiple interactions

Manganese promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]

NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363

G

inter-alpha-trypsin inhibitor heavy chain 2

multiple interactions

Manganese promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]

NCBI chr17:68,375,574...68,411,849
Ensembl chr17:68,375,567...68,411,841

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

Manganese results in decreased expression of JUN protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; NEPP11 compound inhibits the reaction [Manganese results in increased phosphorylation of JUN protein]
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein]
[Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of JUN protein

PMID:15342272 PMID:17043766 PMID:17827730 PMID:22561169 PMID:28035397

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel interacting protein 3

increases expression

Manganese results in increased expression of KCNIP3 mRNA

NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556

G

potassium inwardly-rectifying channel, subfamily J, member 11

multiple interactions

KCNJ11 protein affects the reaction [[Manganese co-treated with Dobutamine] results in increased abundance of Calcium]
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ11 protein

PMID:17189350 PMID:32659473

NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082

G

potassium inwardly-rectifying channel, subfamily J, member 3

increases expression

Manganese results in increased expression of KCNJ3 mRNA

NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124

G

potassium inwardly-rectifying channel, subfamily J, member 8

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ8 protein

NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603

G

keratocan

increases expression

Manganese results in increased expression of KERA mRNA

NCBI chr 7:32,397,382...32,404,837
Ensembl chr 7:32,397,382...32,404,837

G

KH-type splicing regulatory protein

multiple interactions
increases expression

KHSRP protein affects the reaction [Manganese results in increased expression of TP53 protein]
Manganese results in increased expression of KHSRP protein

NCBI chr 9:1,862,555...1,872,403
Ensembl chr 9:1,862,899...1,872,451

G

KiSS-1 metastasis-suppressor

increases expression

Manganese results in increased expression of KISS1 mRNA

NCBI chr13:44,775,106...44,780,707
Ensembl chr13:44,774,823...44,780,612

G

KISS1 receptor

increases expression

Manganese results in increased expression of KISS1R mRNA

NCBI chr 7:9,785,135...9,790,283
Ensembl chr 7:9,785,135...9,788,793

G

KLF transcription factor 4

increases expression

Manganese results in increased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

KLF transcription factor 9

decreases expression

Manganese results in decreased expression of KLF9 mRNA

NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037

G

lysosomal-associated membrane protein 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 protein; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 mRNA]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 protein]

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

G

lysosomal-associated membrane protein 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP2 protein

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

lactate dehydrogenase B

affects expression

Manganese affects the expression of LDHB protein

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

leptin

decreases abundance

LEP gene mutant form results in decreased abundance of Manganese

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

lectin, mannose-binding 2

increases expression

Manganese results in increased expression of LMAN2 mRNA

NCBI chr17:9,269,236...9,286,923
Ensembl chr17:9,269,022...9,287,265

G

lecithin retinol acyltransferase

increases expression

Manganese results in increased expression of LRAT mRNA

NCBI chr 2:168,264,093...168,273,155
Ensembl chr 2:168,266,877...168,273,619

G

leucine-rich repeat kinase 2

increases response to substance
multiple interactions

LRRK2 mutant form results in increased susceptibility to Manganese
LRRK2 mutant form results in increased susceptibility to [Manganese co-treated with SLC6A3 protein]

NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703

G

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LSM2 mRNA

NCBI chr20:3,843,467...3,847,217
Ensembl chr20:3,843,466...3,847,266

G

MAF bZIP transcription factor

increases expression

Manganese results in increased expression of MAF mRNA

NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365

G

MAGE family member D2

decreases expression

Manganese results in decreased expression of MAGED2 mRNA

NCBI chr X:19,733,593...19,741,769
Ensembl chr X:19,733,597...19,740,477

G

mal, T-cell differentiation protein-like

decreases expression

Manganese results in decreased expression of MALL mRNA

NCBI chr 3:114,927,897...114,950,840
Ensembl chr 3:114,927,897...114,950,785

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MAP1LC3B mRNA; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MAP1LC3B mRNA]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 4

multiple interactions
decreases phosphorylation

[Manganese co-treated with Lipopolysaccharides] results in increased activity of and results in increased phosphorylation of MAP2K4 protein; Lipopolysaccharides promotes the reaction [Manganese results in increased activity of MAP2K4 protein]; Manganese promotes the reaction [Lipopolysaccharides results in increased activity of MAP2K4 protein]; Manganese results in increased activity of and results in increased phosphorylation of MAP2K4 protein
Manganese results in decreased phosphorylation of MAP2K4 protein

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen-activated protein kinase kinase kinase 14

multiple interactions

MAP3K14 protein affects the reaction [Manganese promotes the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]

NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

Manganese inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein]
Manganese results in decreased phosphorylation of MAPK1 protein
Manganese results in increased phosphorylation of MAPK1 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Manganese results in increased phosphorylation of MAPK1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein; Deferoxamine promotes the reaction [Manganese results in increased phosphorylation of MAPK1 protein]; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Manganese results in increased phosphorylation of MAPK1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein]

PMID:11933051 PMID:16488514 PMID:16787641 PMID:17043766 PMID:17045426 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

decreases phosphorylation

Manganese results in decreased phosphorylation of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

Manganese inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein]
Manganese results in decreased phosphorylation of MAPK3 protein
Manganese results in increased phosphorylation of MAPK3 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Manganese results in increased phosphorylation of MAPK3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein; Deferoxamine promotes the reaction [Manganese results in increased phosphorylation of MAPK3 protein]; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Manganese results in increased phosphorylation of MAPK3 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein]

PMID:11933051 PMID:16488514 PMID:16787641 PMID:17043766 PMID:17045426 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

Manganese results in increased phosphorylation of MAPK8 protein
[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein]

PMID:17045426 PMID:30951808 PMID:32574669

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

increases phosphorylation
multiple interactions

Manganese results in increased phosphorylation of MAPK9 protein
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]

PMID:17045426 PMID:22561169

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

myelin basic protein

increases expression

Manganese results in increased expression of MBP mRNA

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

melanin-concentrating hormone receptor 1

increases expression

Manganese results in increased expression of MCHR1 mRNA

NCBI chr 7:112,761,554...112,764,746
Ensembl chr 7:112,761,554...112,764,032

G

minichromosome maintenance complex component 4

decreases expression

Manganese results in decreased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 5

decreases expression

Manganese results in decreased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

mucolipin TRP cation channel 3

increases expression

Manganese results in increased expression of MCOLN3 mRNA

NCBI chr 2:235,008,716...235,042,885
Ensembl chr 2:234,966,010...235,043,047

G

malate dehydrogenase 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MDH1 mRNA

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

MDM2 proto-oncogene

multiple interactions
decreases expression

[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein]
Manganese results in decreased expression of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

malic enzyme 3

increases expression

Manganese results in increased expression of ME3 mRNA

NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132

G

MIA SH3 domain containing

increases expression

Manganese results in increased expression of MIA mRNA

NCBI chr 1:82,473,677...82,476,378
Ensembl chr 1:82,473,678...82,475,370

G

midline 1

decreases expression
increases methylation

Manganese results in decreased expression of MID1 mRNA
Manganese results in increased methylation of MID1 promoter

NCBI chr X:24,116,674...24,491,205
Ensembl chr X:24,120,293...24,248,353

G

microRNA 125b-1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of MIR125B1 mRNA

NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052

G

microRNA 582

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR582 mRNA

NCBI chr 2:40,928,571...40,928,651
Ensembl chr 2:40,928,571...40,928,651

G

matrix metallopeptidase 13

increases expression

Manganese results in increased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 14

decreases expression

Manganese results in decreased expression of MMP14 protein

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

decreases expression

Manganese results in decreased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

increases expression

Manganese results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

myeloperoxidase

multiple interactions

[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of MPO protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of MPO protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of MPO protein]

PMID:30844427 PMID:33314588

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mutS homolog 6

decreases expression

Manganese results in decreased expression of MSH6 mRNA

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

metallothionein 2A

multiple interactions

[MT2 protein affects the susceptibility to 3,4,5,3',4'-pentachlorobiphenyl] which results in decreased abundance of Manganese

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mitochondrial carrier 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MTCH2 mRNA

NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189

G

myotubularin 1

decreases expression

Manganese results in decreased expression of MTM1 mRNA

NCBI chr 6:488,923...506,882
Ensembl chr 6:488,969...506,860

G

mechanistic target of rapamycin kinase

decreases phosphorylation
increases phosphorylation
increases expression

Manganese results in decreased phosphorylation of MTOR protein
Manganese results in increased phosphorylation of MTOR protein
Manganese results in increased expression of MTOR mRNA

PMID:17043766 PMID:23997110

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

myosin heavy chain 2

decreases expression

Manganese results in decreased expression of MYH2 mRNA

NCBI chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236

G

myomesin 1

increases expression

Manganese results in increased expression of MYOM1 mRNA

NCBI chr 9:110,916,156...111,039,344
Ensembl chr 9:110,915,943...111,039,344

G

myelin transcription factor 1-like

increases expression

Manganese results in increased expression of MYT1L mRNA

PMID:17175027 PMID:26745496

NCBI chr 6:46,164,742...46,564,234
Ensembl chr 6:46,428,150...46,561,671

G

nicotinamide phosphoribosyltransferase

increases expression

Manganese results in increased expression of NAMPT mRNA

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

N-myc downstream regulated 1

increases expression

Manganese results in increased expression of NDRG1 protein

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

neurofilament light chain

multiple interactions
increases expression

HTT protein mutant form inhibits the reaction [Manganese results in increased expression of NEFL protein]

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

NFE2 like bZIP transcription factor 2

multiple interactions

[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFE2L2 protein; Manganese results in increased expression of and results in increased localization of NFE2L2 protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in increased abundance of Manganese

PMID:17573173 PMID:23764462 PMID:37415728

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor I/B

increases expression

Manganese results in increased expression of NFIB mRNA

NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479

G

nuclear factor I X

decreases expression

Manganese results in decreased expression of NFIX mRNA

NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265

G

nuclear factor kappa B subunit 1

multiple interactions

[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; MAP3K14 protein affects the reaction [Manganese promotes the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]; NFKBIA protein affects the reaction [Manganese results in increased expression of NOS2 mRNA]; NFKBIA protein affects the reaction [Manganese results in increased expression of NOS2 protein]

PMID:15010209 PMID:16168523 PMID:16488514

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nuclear transcription factor Y subunit beta

decreases expression

Manganese results in decreased expression of NFYB mRNA

NCBI chr 7:20,964,988...20,980,569
Ensembl chr 7:20,964,993...20,980,565

G

nerve growth factor

multiple interactions

[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein; [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein; [Manganese co-treated with NGF protein] results in decreased expression of PPM1D protein; [Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein; [Manganese co-treated with NGF protein] results in increased expression of and affects the localization of TP53 protein; [Manganese co-treated with NGF protein] results in increased expression of BAX protein; [Manganese co-treated with NGF protein] results in increased phosphorylation of and results in increased expression of TP53 protein; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein]; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased cleavage of PARP1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]

PMID:25448048 PMID:25791630

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

N-myristoyltransferase 1

multiple interactions

[Manganese binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in decreased activity of NMT1 protein

NCBI chr10:87,988,826...88,025,405
Ensembl chr10:87,988,826...88,022,648

G

nicotinamide N-methyltransferase

increases activity

Manganese results in increased activity of NNMT protein

NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655

G

nitric oxide synthase 1

decreases expression

Manganese results in decreased expression of NOS1 mRNA

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

multiple interactions
decreases activity
increases expression
decreases methylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of NOS2 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of NOS2 protein; Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]; NFKBIA protein affects the reaction [Manganese results in increased expression of NOS2 mRNA]; NFKBIA protein affects the reaction [Manganese results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 protein]
Manganese results in decreased activity of NOS2 protein
Manganese results in increased expression of NOS2 mRNA; Manganese results in increased expression of NOS2 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [Manganese results in increased abundance of Reactive Oxygen Species] promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Manganese results in increased expression of and results in increased activity of NOS2 protein; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
Manganese results in decreased methylation of NOS2 exon

PMID:15010209 PMID:16168523 PMID:16417967 PMID:16488514 PMID:16551646 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

Manganese inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 4

decreases expression

Manganese results in decreased expression of NOTCH4 mRNA

NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465

G

natriuretic peptide A

decreases expression

Manganese results in decreased expression of NPPA mRNA

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

NAD(P)H quinone dehydrogenase 1

increases activity

Manganese results in increased activity of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 2, group F, member 1

decreases expression
increases methylation

Manganese results in decreased expression of NR2F1 mRNA
Manganese results in increased methylation of NR2F1 promoter

NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123

G

neuregulin 2

increases expression

Manganese results in increased expression of NRG2 mRNA

NCBI chr18:27,616,542...27,798,505
Ensembl chr18:27,619,661...27,798,505

G

neuropilin 1

increases expression

Manganese results in increased expression of NRP1 mRNA

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

G

neurotrophin 3

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTF3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTF3 protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTF3 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTRK3 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein]; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

neurotrophic receptor tyrosine kinase 1

decreases expression

Manganese results in decreased expression of NTRK1 protein

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

neurotrophic receptor tyrosine kinase 3

multiple interactions

NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTRK3 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTRK3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of NTRK3 protein]

NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286

G

nuclear casein kinase and cyclin-dependent kinase substrate 1

decreases expression

Manganese results in decreased expression of NUCKS1 mRNA

NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229

G

nudix hydrolase 9

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]]; Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]

NCBI chr14:5,675,376...5,693,332
Ensembl chr14:5,675,382...5,693,142

G

8-oxoguanine DNA glycosylase

decreases expression

Manganese results in decreased expression of OGG1 mRNA

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

olfactomedin 1

increases expression

Manganese results in increased expression of OLFM1 mRNA

NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239

G

opioid receptor, delta 1

multiple interactions

Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]; Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 protein]]

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

multiple interactions

Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRK1 protein]

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

multiple interactions

Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Zinc inhibits the reaction [Manganese promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]]

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

prolyl 4-hydroxylase subunit beta

increases expression
increases metabolic processing
multiple interactions

Manganese results in increased expression of P4HB mRNA
Manganese results in increased metabolism of P4HB protein
Manganese affects the reaction [P4HB protein binds to SNCA protein]; Manganese results in increased expression of and results in increased activity of P4HB protein

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

pappalysin

increases expression

Manganese results in increased expression of PAPPA mRNA

NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666

G

Parkinsonism associated deglycase

decreases expression

Manganese results in decreased expression of PARK7 protein

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

[Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased cleavage of PARP1 protein]
Manganese results in increased cleavage of PARP1 protein
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein]

PMID:25448048 PMID:25791630 PMID:29115570

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

poly (ADP-ribose) polymerase family, member 14

increases expression

Manganese results in increased expression of PARP14 mRNA

NCBI chr11:64,902,848...64,934,916
Ensembl chr11:64,902,785...64,934,916

G

protocadherin 7

increases expression

Manganese results in increased expression of PCDH7 mRNA

NCBI chr14:52,471,801...52,901,696
Ensembl chr14:52,475,610...52,902,051
Ensembl chr14:52,475,610...52,902,051

G

protocadherin alpha 6

increases expression

Manganese results in increased expression of PCDHA6 mRNA

Ensembl chr18:28,581,225...28,846,211

G

phosphodiesterase 4B

increases expression
multiple interactions

Manganese results in increased expression of PDE4B protein
Rolipram inhibits the reaction [Manganese results in increased expression of PDE4B protein]

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

phosphodiesterase 6B

increases expression

Manganese results in increased expression of PDE6B mRNA

NCBI chr14:1,323,310...1,366,450
Ensembl chr14:1,323,310...1,366,450

G

phosphodiesterase 6H

increases expression

Manganese results in increased expression of PDE6H mRNA

NCBI chr 4:169,857,793...169,872,969
Ensembl chr 4:169,857,812...169,872,969

G

pyruvate dehydrogenase kinase 1

increases expression

Manganese results in increased expression of PDK1 mRNA

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

placental growth factor

increases expression

Manganese results in increased expression of PGF mRNA

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

PHD and ring finger domains 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of PHRF1 mRNA

NCBI chr 1:196,333,663...196,366,901
Ensembl chr 1:196,333,903...196,366,892

G

putative homeodomain transcription factor 1

decreases expression

Manganese results in decreased expression of PHTF1 mRNA

NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:191,473,130...191,512,078

G

phospholipase C, epsilon 1

increases expression

Manganese results in increased expression of PLCE1 mRNA

NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438

G

phospholamban

decreases expression

Manganese results in decreased expression of PLN mRNA

NCBI chr20:32,629,537...32,639,559

G

pancreatic lipase

increases expression

Manganese results in increased expression of PNLIP mRNA

NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654

G

POU class 1 homeobox 1

increases expression

Manganese results in increased expression of POU1F1 mRNA

NCBI chr11:3,316,818...3,334,804
Ensembl chr11:3,317,058...3,334,801

G

peroxisome proliferator-activated receptor gamma

multiple interactions

[1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane binds to and results in increased activity of PPARG protein] inhibits the reaction [Manganese results in increased chemical synthesis of Nitric Oxide]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

increases expression
multiple interactions

Manganese results in increased expression of PPARGC1A protein
[manganese chloride results in increased abundance of Manganese] affects the reaction [STAT3 protein binds to PPARGC1A protein]

PMID:24787138 PMID:34018660

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

decreases expression
multiple interactions

Manganese results in decreased expression of PPM1D protein
[Manganese co-treated with NGF protein] results in decreased expression of PPM1D protein; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein]; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased cleavage of PARP1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]

NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

increases phosphorylation

Manganese results in increased phosphorylation of PPP1R1B protein

NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775

G

peroxiredoxin 6

affects expression

Manganese affects the expression of PRDX6 protein

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

DNA primase subunit 1

decreases expression

Manganese results in decreased expression of PRIM1 mRNA

NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526

G

DNA primase subunit 2

decreases expression

Manganese results in decreased expression of PRIM2 mRNA

NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030

G

protein kinase cAMP-activated catalytic subunit alpha

decreases expression
multiple interactions

Manganese results in decreased expression of PRKACA protein
[manganese chloride results in increased abundance of Manganese] which results in increased activity of PRKACA protein

PMID:25981801 PMID:30951808

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

protein kinase C, alpha

increases phosphorylation
decreases expression

Manganese results in increased phosphorylation of PRKCA protein
Manganese results in decreased expression of PRKCA protein

PMID:21812036 PMID:25981801

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, delta

increases phosphorylation
multiple interactions

Manganese results in increased phosphorylation of PRKCD protein
Manganese promotes the reaction [PRKCD protein binds to SLC1A5 protein]; Manganese promotes the reaction [PRKCD protein binds to SLC38A3 protein]; Manganese results in increased cleavage of and results in increased activity of PRKCD protein
SNCA protein inhibits the reaction [Manganese results in increased cleavage of and results in increased activity of PRKCD protein]

PMID:21812036 PMID:25416158

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase D1

increases expression

Manganese results in increased expression of PRKD1 mRNA

NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042

G

parkin RBR E3 ubiquitin protein ligase

decreases expression
decreases transport
affects response to substance
increases expression

Manganese results in decreased expression of PRKN mRNA
PRKN protein results in decreased transport of Manganese
PRKN gene mutant form affects the susceptibility to Manganese
Manganese results in increased expression of PRKN protein

PMID:19781568 PMID:20089134 PMID:20798247 PMID:22841634 PMID:28826884

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prolactin

decreases expression
multiple interactions

Manganese results in decreased expression of PRL protein
Manganese inhibits the reaction [PRL protein binds to PRLR protein]

PMID:6197504 PMID:19595304

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prolactin family 7, subfamily A, member 3

increases expression

Manganese results in increased expression of PRL7A3 mRNA

NCBI chr17:37,086,164...37,099,039
Ensembl chr17:37,086,136...37,099,037

G

prolactin receptor

multiple interactions

Manganese inhibits the reaction [PRL protein binds to PRLR protein]

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

prion protein

increases stability
multiple interactions
affects binding

Manganese results in increased stability of PRNP protein
[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]; [[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of PRNP protein; CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]

PMID:16595185 PMID:20176619

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Manganese results in increased expression of PTGS2 mRNA; Manganese results in increased expression of PTGS2 protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of PTGS2 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of PTGS2 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of PTGS2 protein]
[Manganese co-treated with Lipopolysaccharides] results in increased expression of PTGS2 mRNA

PMID:17175027 PMID:17827730 PMID:20589745 PMID:30844427 PMID:33314588

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2 beta

decreases expression

Manganese results in decreased expression of PTK2B mRNA

NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282

G

pentraxin 3

increases expression

Manganese results in increased expression of PTX3 mRNA

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

parvalbumin

decreases expression
increases methylation

Manganese results in decreased expression of PVALB mRNA
Manganese results in increased methylation of PVALB promoter

NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561

G

PVR cell adhesion molecule

decreases expression

Manganese results in decreased expression of PVR mRNA

NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715

G

RAB21, member RAS oncogene family

decreases expression

Manganese results in decreased expression of RAB21 mRNA

NCBI chr 7:50,904,050...50,928,890
Ensembl chr 7:50,904,057...50,928,839

G

RAB23, member RAS oncogene family

decreases expression

Manganese results in decreased expression of RAB23 mRNA

NCBI chr 9:35,943,522...35,967,367
Ensembl chr 9:35,944,085...35,966,927

G

RAB3D, member RAS oncogene family

decreases expression

Manganese results in decreased expression of RAB3D mRNA

NCBI chr 8:20,438,622...20,449,269
Ensembl chr 8:20,439,294...20,449,185

G

RELA proto-oncogene, NF-kB subunit

affects localization
multiple interactions

Manganese affects the localization of RELA protein
1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Manganese affects the localization of RELA protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of RELA protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of RELA protein]; Manganese promotes the reaction [RELA protein binds to HDAC1 protein]; Manganese promotes the reaction [YY1 protein binds to RELA protein]
[manganese chloride results in increased abundance of Manganese] which affects the localization of RELA protein; Acetylcysteine affects the reaction [[manganese chloride results in increased abundance of Manganese] which affects the localization of RELA protein]; alpha-Tocopherol affects the reaction [[manganese chloride results in increased abundance of Manganese] which affects the localization of RELA protein]; IkK-16 compound affects the reaction [[manganese chloride results in increased abundance of Manganese] which affects the localization of RELA protein]
[Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of RELA protein

PMID:22645130 PMID:24469401 PMID:28035397 PMID:33314588 PMID:34310962

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

replication factor C subunit 5

decreases expression

Manganese results in decreased expression of RFC5 mRNA

NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312

G

regulator of G-protein signaling 2

increases expression

Manganese results in increased expression of RGS2 mRNA

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

regulator of G-protein signaling 5

decreases expression

Manganese results in decreased expression of RGS5 mRNA

NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518

G

regulator of G-protein signaling 6

increases expression

Manganese results in increased expression of RGS6 mRNA

NCBI chr 6:102,264,451...102,796,311
Ensembl chr 6:102,264,447...102,824,753

G

Ras homolog, mTORC1 binding

increases expression

Manganese results in increased expression of RHEB mRNA

NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160

G

ring finger protein 145

increases expression

Manganese results in increased expression of RNF145 mRNA

NCBI chr10:29,006,391...29,050,788
Ensembl chr10:29,011,548...29,050,781

G

retinoid isomerohydrolase RPE65

multiple interactions
decreases uptake
increases uptake

[retinylamine results in decreased activity of RPE65 protein] which results in decreased uptake of Manganese; Retinaldehyde inhibits the reaction [RPE65 exon mutant form results in decreased uptake of Manganese]
RPE65 protein results in increased uptake of Manganese

NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403

G

ribosomal protein L37

decreases expression

Manganese results in decreased expression of RPL37 mRNA

NCBI chr 2:54,215,469...54,217,429
Ensembl chr 2:54,215,469...54,217,442

G

ribosomal protein S6 kinase B1

multiple interactions

[[manganese chloride results in increased abundance of Manganese] which co-treated with Sirolimus] results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

S100 calcium binding protein A6

increases expression

Manganese results in increased expression of S100A6 mRNA

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

SUMO1 activating enzyme subunit 1

multiple interactions

Manganese inhibits the reaction [HTT protein mutant form affects the expression of SAE1 protein]

NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986

G

sodium voltage-gated channel beta subunit 3

increases expression

Manganese results in increased expression of SCN3B mRNA

NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868

G

sodium voltage-gated channel alpha subunit 7

decreases expression

Manganese results in decreased expression of SCN7A mRNA

NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256

G

secernin 1

affects expression

Manganese affects the expression of SCRN1 protein

NCBI chr 4:83,632,125...83,694,225
Ensembl chr 4:83,632,131...83,693,852

G

syndecan binding protein 2

decreases expression

Manganese results in decreased expression of SDCBP2 mRNA

NCBI chr 3:140,060,746...140,098,063
Ensembl chr 3:140,070,540...140,098,057

G

serpin family B member 2

increases expression

Manganese results in increased expression of SERPINB2 mRNA

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

serpin family E member 1

increases stability

Manganese results in increased stability of SERPINE1 protein

PMID:21280127 PMID:21280128

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

surfactant protein B

increases expression

Manganese results in increased expression of SFTPB mRNA

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

G

sideroflexin 5

increases expression

Manganese results in increased expression of SFXN5 mRNA

NCBI chr 4:117,750,213...117,869,826
Ensembl chr 4:117,752,806...117,869,794

G

SH2 domain containing 3C

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of SH2D3C mRNA

NCBI chr 3:16,010,622...16,046,491
Ensembl chr 3:16,010,625...16,046,484

G

sirtuin 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 2

increases expression

Manganese results in increased expression of SIRT2 mRNA

NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975

G

SIX homeobox 3

increases expression

Manganese results in increased expression of SIX3 mRNA

NCBI chr 6:9,039,017...9,043,336
Ensembl chr 6:9,036,434...9,053,301

G

solute carrier family 11 member 2

multiple interactions
increases expression
decreases uptake
decreases metabolic processing
increases abundance
increases uptake

[[manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper; [[Manganese results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper; [Deferoxamine co-treated with Manganese] results in increased expression of SLC11A2; [manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese; [Manganese results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese; Iron inhibits the reaction [SLC11A2 protein results in increased uptake of Manganese]; Manganese promotes the reaction [SLC11A2 protein results in increased transport of Iron]; Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]; SLC11A2 protein affects the reaction [Manganese results in increased transport of Iron]
Manganese results in increased expression of SLC11A2 mRNA
SLC11A2 protein mutant form results in decreased uptake of Manganese
SLC11A2 protein mutant form results in decreased metabolism of Manganese
[Deferoxamine results in increased expression of SLC11A2 protein] which results in increased uptake of Manganese; Manganese inhibits the reaction [SLC11A2 protein results in increased transport of Ferrous Compounds]
Manganese results in increased expression of SLC11A2 mRNA; Manganese results in increased expression of SLC11A2 protein
SLC11A2 protein results in increased abundance of Manganese
SLC11A2 protein results in increased uptake of Manganese; SLC11A2 results in increased uptake of Manganese
[manganese chloride results in increased abundance of Manganese] which results in increased expression of SLC11A2 mRNA

PMID:11933051 PMID:16705042 PMID:16729984 PMID:17116743 PMID:17175027 More...

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 12 member 2

multiple interactions
increases expression
increases oxidation

1,3-dimethylthiourea inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; 1,3-dimethylthiourea inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; tempol inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; tempol inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Uric Acid inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Uric Acid inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Vitamin E inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Vitamin E inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 16 member 3

increases expression

Manganese results in increased expression of SLC16A3 mRNA

NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562

G

solute carrier family 18 member A2

decreases expression

Manganese results in decreased expression of SLC18A2 mRNA

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 1 member 2

multiple interactions
decreases expression

1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]; Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; Manganese promotes the reaction [YY1 protein binds to SLC1A2 promoter]; romidepsin inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; trichostatin A inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; vorinostat inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; YY1 protein affects the reaction [Manganese results in decreased expression of SLC1A2 mRNA]
Manganese results in decreased expression of SLC1A2 mRNA; Manganese results in decreased expression of SLC1A2 protein
Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]; Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 mRNA]; Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A2 protein]
[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 mRNA]; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein]; IkK-16 compound inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 mRNA]; IkK-16 compound inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein]

PMID:22645130 PMID:24469401 PMID:28610743 PMID:34310962 PMID:34800614

NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 1 member 3

multiple interactions
decreases expression

Estradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]; Estradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]; Tamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]; Tamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]
Manganese results in decreased expression of SLC1A3 mRNA; Manganese results in decreased expression of SLC1A3 protein
Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]; Butyric Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]; Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]; Valproic Acid inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]

PMID:19453300 PMID:28610743

NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605

G

solute carrier family 1 member 5

multiple interactions

Manganese promotes the reaction [PRKCD protein binds to SLC1A5 protein]

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22, member 15

decreases expression

Manganese results in decreased expression of SLC22A15 mRNA

NCBI chr 2:189,298,836...189,359,902
Ensembl chr 2:189,298,832...189,358,792

G

solute carrier family 2 member 13

increases expression

Manganese results in increased expression of SLC2A13 mRNA

NCBI chr 7:122,399,329...122,726,605
Ensembl chr 7:122,399,330...122,726,605

G

solute carrier family 30, member 10

multiple interactions
affects transport
decreases abundance
increases abundance
increases secretion
decreases expression

[IL6 protein results in decreased expression of SLC30A10 mRNA] which results in decreased export of Manganese; [IL6 protein results in decreased expression of SLC30A10 protein] which results in decreased export of Manganese; Edetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]
SLC30A10 gene SNP affects the transport of Manganese
SLC30A10 gene SNP results in decreased abundance of Manganese
SLC30A10 gene mutant form results in increased abundance of Manganese; SLC30A10 gene SNP results in increased abundance of Manganese
SLC30A10 protein results in increased secretion of Manganese
Manganese results in decreased expression of SLC30A10 mRNA
[manganese chloride results in increased abundance of Manganese] which results in increased expression of SLC30A10 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of SLC30A10 protein

PMID:22926781 PMID:24576911 PMID:26025379 PMID:26628504 PMID:28860195 More...

NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103

G

solute carrier family 38, member 1

decreases expression

Manganese results in decreased expression of SLC38A1 mRNA

NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218

G

solute carrier family 38, member 10

increases expression

Manganese results in increased expression of SLC38A10 mRNA

NCBI chr10:105,386,836...105,436,636
Ensembl chr10:105,386,836...105,436,636

G

solute carrier family 38, member 3

multiple interactions
decreases expression

Manganese promotes the reaction [PRKCD protein binds to SLC38A3 protein]
Manganese results in decreased expression of SLC38A3 mRNA

PMID:17468184 PMID:21812036

NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988

G

solute carrier family 39 member 14

increases expression
increases import
affects uptake
multiple interactions

Manganese results in increased expression of SLC39A14 mRNA
SLC39A14 protein results in increased import of Manganese
SLC39A14 protein affects the uptake of Manganese
SLC39A14 protein results in increased import of and results in increased secretion of Manganese

PMID:17065364 PMID:22898811 PMID:24576911 PMID:28860195

NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524

G

solute carrier family 39 member 8

multiple interactions
increases uptake
increases import
affects transport

Manganese inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]; SLC39A8 protein results in increased uptake of [Manganese co-treated with Bicarbonates]
SLC39A8 protein results in increased uptake of Manganese
SLC39A8 protein results in increased import of Manganese
Manganese inhibits the reaction [SLC39A8 protein results in increased import of Iron]
SLC39A8 gene SNP affects the transport of Manganese; SLC39A8 SNP affects the transport of Manganese

PMID:16638970 PMID:22898811 PMID:26025379 PMID:28917719

NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129

G

solute carrier family 40 member 1

multiple interactions
increases export
decreases expression

Cobalt inhibits the reaction [SLC40A1 protein results in increased export of Manganese]; Iron inhibits the reaction [SLC40A1 protein results in increased export of Manganese]; Nickel inhibits the reaction [SLC40A1 protein results in increased export of Manganese]
Manganese results in decreased expression of SLC40A1 mRNA

PMID:22178646 PMID:29020610

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

solute carrier family 4 member 10

decreases expression

Manganese results in decreased expression of SLC4A10 mRNA

NCBI chr 3:46,665,076...46,959,088
Ensembl chr 3:46,665,265...46,957,268

G

solute carrier family 5 member 7

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC5A7 mRNA

NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258

G

solute carrier family 6 member 3

decreases expression
increases response to substance
multiple interactions
affects localization
affects response to substance

Manganese results in decreased expression of SLC6A3 protein
SLC6A3 protein results in increased susceptibility to Manganese
LRRK2 mutant form results in increased susceptibility to [Manganese co-treated with SLC6A3 protein]
Manganese affects the localization of SLC6A3 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC6A3 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC6A3 protein]
SLC6A3 gene SNP affects the susceptibility to Manganese

PMID:16571372 PMID:18206288 PMID:23313730 PMID:23628791 PMID:34590183 More...

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 6 member 6

increases expression

Manganese results in increased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

solute carrier organic anion transporter family, member 1a4

decreases expression

Manganese results in decreased expression of SLCO1A4 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

small integral membrane protein 14

increases expression

Manganese results in increased expression of SMIM14 mRNA

NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760

G

synuclein alpha

increases expression
multiple interactions

Manganese results in increased expression of SNCA mRNA
[manganese chloride results in increased abundance of Manganese] which results in increased expression of SNCA protein; Manganese promotes the reaction [SNCA protein binds to SNCA protein]; SNCA gene inhibits the reaction [DJR-1.1 mutant form results in increased transport of and results in increased abundance of Manganese]; SNCA gene inhibits the reaction [PDR-1 mutant form results in increased transport of and results in increased abundance of Manganese]; SNCA protein inhibits the reaction [Manganese affects the localization of CYCS protein]; SNCA protein inhibits the reaction [Manganese results in increased activity of CASP3 protein]; SNCA protein inhibits the reaction [Manganese results in increased activity of CASP9 protein]; SNCA protein inhibits the reaction [Manganese results in increased cleavage of and results in increased activity of PRKCD protein]
Manganese affects the reaction [P4HB protein binds to SNCA protein]; Manganese promotes the reaction [SNCA protein binds to and results in increased expression of SNCA protein]

PMID:19781568 PMID:24452053 PMID:24777576 PMID:25416158 PMID:32659473

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

superoxide dismutase 1

increases uptake

SOD1 protein results in increased uptake of Manganese

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression
multiple interactions
increases activity

Manganese results in increased expression of SOD2 mRNA; Manganese results in increased expression of SOD2 protein
Manganese deficiency results in increased expression of SOD2 protein
Paroxetine inhibits the reaction [Manganese deficiency results in increased expression of SOD2 protein]
2-oxothiazolidine-4-carboxylic acid promotes the reaction [Manganese results in increased expression of SOD2 protein]; Manganese inhibits the reaction [Cadmium Chloride results in decreased activity of SOD2 protein]
Manganese results in increased activity of SOD2 protein

PMID:12204541 PMID:17175027 PMID:18317567 PMID:19093460 PMID:21312047 More...

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sortilin 1

decreases expression

Manganese results in decreased expression of SORT1 mRNA

NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354

G

sclerostin domain containing 1

decreases expression

Manganese results in decreased expression of SOSTDC1 mRNA

NCBI chr 6:53,051,336...53,055,510
Ensembl chr 6:53,051,354...53,055,579

G

Sp1 transcription factor

multiple interactions

Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]; Manganese results in increased phosphorylation of and results in increased activity of SP1 protein

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

sperm autoantigenic protein 17

decreases expression

Manganese results in decreased expression of SPA17 mRNA

NCBI chr 8:37,307,432...37,318,519
Ensembl chr 8:37,307,557...37,318,639

G

spectrin, alpha, non-erythrocytic 1

multiple interactions
increases cleavage

aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein]; calpain inhibitor III inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein]

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

G

sequestosome 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of SQSTM1 protein; Sirolimus inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of SQSTM1 protein]; SQSTM1 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

[Manganese binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in decreased expression of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

steroidogenic acute regulatory protein

decreases expression

Manganese results in decreased expression of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 3

multiple interactions

[manganese chloride results in increased abundance of Manganese] affects the reaction [STAT3 protein binds to PPARGC1A protein]; [manganese chloride results in increased abundance of Manganese] which affects the localization of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

storkhead box 1

decreases expression

Manganese results in decreased expression of STOX1 mRNA

NCBI chr20:30,598,284...30,666,371
Ensembl chr20:30,598,168...30,666,939

G

sulfotransferase family 1C member 3

increases expression

Manganese results in increased expression of SULT1C1 mRNA

NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030

G

synapsin I

increases phosphorylation

Manganese results in increased phosphorylation of SYN1 protein

NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396

G

TGF-beta activated kinase 1/MAP3K7 binding protein 1

affects binding

Manganese binds to TAB1 protein

NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058

G

tachykinin receptor 1

decreases expression

Manganese results in decreased expression of TACR1 mRNA

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

transgelin 2

decreases expression

Manganese results in decreased expression of TAGLN2 mRNA

NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972

G

T-box transcription factor 18

increases expression

Manganese results in increased expression of TBX18 mRNA

NCBI chr 8:88,652,054...88,680,081
Ensembl chr 8:88,652,054...88,680,058

G

transcriptional and immune response regulator

increases expression

Manganese results in increased expression of TCIM mRNA

NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581

G

transferrin

increases uptake
affects binding
multiple interactions

Manganese results in increased uptake of TF protein
Manganese binds to TF protein; TF protein binds to Manganese
[Iron deficiency co-treated with Manganese] results in increased expression of TF protein
[Aluminum binds to TF protein] which results in decreased uptake of Manganese; [Manganese binds to TF protein] which results in decreased uptake of Manganese

PMID:8782865 PMID:17060373 PMID:17469137 PMID:18546093

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transcription factor AP-2 alpha

increases expression

Manganese results in increased expression of TFAP2A protein

NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507

G

transcription factor AP-2 beta

increases expression

Manganese results in increased expression of TFAP2B mRNA

NCBI chr 9:21,786,251...21,816,054
Ensembl chr 9:21,786,258...21,814,520

G

transcription factor EB

multiple interactions

[manganese chloride results in increased abundance of Manganese] which affects the localization of TFEB protein; [manganese chloride results in increased abundance of Manganese] which results in decreased activity of TFEB protein; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which affects the localization of TFEB protein]

NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714

G

transferrin receptor

increases expression

Manganese results in increased expression of TFRC mRNA; Manganese results in increased expression of TFRC protein

PMID:16545456 PMID:16568477 PMID:16705042 PMID:16740617 PMID:17469137 More...

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor, beta 1

decreases expression
multiple interactions

Manganese results in decreased expression of TGFB1 mRNA
[manganese chloride results in increased abundance of Manganese] which affects the expression of TGFB1 mRNA; [manganese chloride results in increased abundance of Manganese] which affects the expression of TGFB1 protein

PMID:16476481 PMID:19453300 PMID:34018660

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 1

decreases expression

Manganese results in decreased expression of TGFBR1 mRNA

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

tyrosine hydroxylase

decreases expression
multiple interactions

Manganese results in decreased expression of TH mRNA; Manganese results in decreased expression of TH protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of TH protein]

PMID:16943606 PMID:19781568 PMID:20224926 PMID:20798247 PMID:34590183

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

transmembrane protein 255B

increases expression

Manganese results in increased expression of TMEM255B mRNA

NCBI chr16:76,079,840...76,108,179
Ensembl chr16:76,079,845...76,106,795

G

tumor necrosis factor

multiple interactions
increases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of TNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of TNF protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of TNF protein]; Manganese inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; SB 203580 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; U 0126 inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]
[manganese chloride results in increased abundance of Manganese] which results in increased expression of TNF mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of TNF protein; [Manganese co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]
Manganese results in increased expression of TNF mRNA; Manganese results in increased expression of TNF protein
[manganese chloride results in increased abundance of Manganese] which results in increased secretion of TNF protein; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased secretion of TNF protein]

PMID:16168523 PMID:16488514 PMID:18547589 PMID:19782702 PMID:20224926 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 6

multiple interactions

Manganese promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]; Manganese promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

G

TNF receptor superfamily member 25

increases expression

Manganese results in increased expression of TNFRSF25 mRNA

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341

G

trinucleotide repeat containing adaptor 6A

increases expression

Manganese results in increased expression of TNRC6A mRNA

NCBI chr 1:177,561,898...177,715,669
Ensembl chr 1:177,646,030...177,715,660

G

tumor protein p53

increases response to substance
multiple interactions
increases expression

TP53 protein results in increased susceptibility to Manganese
[manganese chloride results in increased abundance of Manganese] which results in increased expression of TP53 protein; [Manganese co-treated with NGF protein] results in increased expression of and affects the localization of TP53 protein; [Manganese co-treated with NGF protein] results in increased phosphorylation of and results in increased expression of TP53 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of TP53 protein]; KHSRP protein affects the reaction [Manganese results in increased expression of TP53 protein]; Manganese results in increased phosphorylation of and results in increased expression of TP53 protein; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]
Manganese results in increased expression of TP53 mRNA; Manganese results in increased expression of TP53 protein

PMID:23997110 PMID:24845367 PMID:25027559 PMID:25448048 PMID:25791630 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

two pore segment channel 1

increases expression

Manganese results in increased expression of TPCN1 mRNA

NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626

G

transient receptor potential cation channel, subfamily C, member 6

increases transport
multiple interactions
increases uptake

TRPC6 protein results in increased transport of Manganese
1,2-dioctanoylglycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]; 1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]; Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Manganese]; Flufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]]

PMID:11179201 PMID:11535132

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

G

transient receptor potential cation channel, subfamily M, member 1

increases expression

Manganese results in increased expression of TRPM1 mRNA

NCBI chr 1:117,718,896...117,835,434
Ensembl chr 1:117,718,896...117,834,605

G

transient receptor potential cation channel, subfamily M, member 4

increases expression

Manganese results in increased expression of TRPM4 mRNA

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

G

transient receptor potential cation channel, subfamily M, member 7

increases uptake

TRPM7 protein results in increased uptake of Manganese

NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190

G

transient receptor potential cation channel, subfamily V, member 3

decreases expression

Manganese results in decreased expression of TRPV3 mRNA

NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296

G

transient receptor potential cation channel, subfamily V, member 6

increases uptake

TRPV6 protein results in increased uptake of Manganese

NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017

G

testis specific 10

increases expression

Manganese results in increased expression of TSGA10 mRNA

NCBI chr 9:39,991,203...40,098,259
Ensembl chr 9:39,991,830...40,098,232

G

teashirt zinc finger homeobox 2

increases expression

Manganese results in increased expression of TSHZ2 mRNA

NCBI chr 3:158,405,469...158,666,915
Ensembl chr 3:158,405,423...158,850,128

G

tyrosinase-related protein 1

decreases expression

Manganese results in decreased expression of TYRP1 mRNA

PMID:17175027 PMID:26745496

NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516

G

ubiquitin A-52 residue ribosomal protein fusion product 1

decreases expression

Manganese results in decreased expression of UBA52 mRNA

NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807

G

ubiquilin 1

multiple interactions
decreases expression

HTT protein mutant form inhibits the reaction [Manganese results in decreased expression of UBQLN1 protein]

NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090

G

ubiquitin C-terminal hydrolase L1

decreases expression

Manganese results in decreased expression of UCHL1 protein

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

G

urocortin

multiple interactions

astressin inhibits the reaction [UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Manganese]]; UCN protein inhibits the reaction [Thapsigargin results in increased uptake of Manganese]

NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950

G

ubiquitin specific peptidase 15

decreases expression

Manganese results in decreased expression of USP15 mRNA

NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721

G

ubiquitin specific peptidase 18

increases expression

Manganese results in increased expression of USP18 mRNA

NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144

G

ubiquitin specific peptidase 45

decreases expression

Manganese results in decreased expression of USP45 mRNA

NCBI chr 5:35,318,621...35,392,090
Ensembl chr 5:35,318,635...35,389,420

G

UV radiation resistance associated

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of UVRAG mRNA; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of UVRAG mRNA]

NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136

G

voltage-dependent anion channel 1

increases expression

Manganese deficiency results in increased expression of VDAC1 protein

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

vascular endothelial growth factor A

increases expression

Manganese results in increased expression of VEGFA mRNA

PMID:17175027 PMID:17467022

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vanin 3

increases expression

Manganese results in increased expression of VNN3 mRNA

NCBI chr 1:21,571,364...21,583,626
Ensembl chr 1:21,571,364...21,583,626

G

vacuolar protein sorting 13 homolog A

decreases expression

Manganese results in decreased expression of VPS13A mRNA

NCBI chr 1:213,901,999...214,128,638
Ensembl chr 1:213,901,999...214,128,555

G

WD repeat domain, phosphoinositide interacting 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of WIPI1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of WIPI1 protein; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of WIPI1 mRNA]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of WIPI1 protein]

NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846

G

WT1 transcription factor

decreases expression

Manganese results in decreased expression of WT1 mRNA

NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643

G

X-box binding protein 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of XBP1 protein alternative form; [manganese chloride results in increased abundance of Manganese] which results in increased splicing of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

YTH N6-methyladenosine RNA binding protein C2

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of YTHDC2 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of YTHDC2 protein; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA]; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein]

NCBI chr18:37,266,559...37,331,681
Ensembl chr18:37,265,836...37,331,023

G

YY1 transcription factor

multiple interactions
increases expression

Manganese promotes the reaction [YY1 protein binds to HDAC1 protein]; Manganese promotes the reaction [YY1 protein binds to RELA protein]; Manganese promotes the reaction [YY1 protein binds to SLC1A2 promoter]; YY1 protein affects the reaction [Manganese results in decreased expression of SLC1A2 mRNA]
Manganese results in increased expression of YY1 mRNA; Manganese results in increased expression of YY1 protein
[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]; [manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]; [manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein]; IkK-16 compound inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; IkK-16 compound inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein]

PMID:24469401 PMID:34310962 PMID:34800614

NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747

G

zinc finger protein 41

increases expression

Manganese results in increased expression of ZFP41 mRNA

NCBI chr 7:107,307,303...107,320,164
Ensembl chr 7:107,306,867...107,320,270

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19831
chemical entity	19829
molecular entity	19829
transition element molecular entity	16845
manganese group molecular entity	2093
manganese molecular entity	2093
elemental manganese	443
manganese(0)	441
Path 2
Term	Annotations
CHEBI ontology	19831
subatomic particle	19829
composite particle	19829
hadron	19829
baryon	19829
nucleon	19829
atomic nucleus	19829
atom	19829
metal atom	17722
transition element atom	17091
d-block element atom	17084
manganese group element atom	2093
manganese group molecular entity	2093
manganese molecular entity	2093
elemental manganese	443
manganese(0)	441

paths to the root