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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730870
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A1
Name: cytochrome P450 family 1 subfamily A member 1
Acc ID: CHEBI:34757
Term: fenitrothion
Definition: An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.
Chemical ID: MESH:D005278
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A1decreases activityEXP 6480464CTDFenitrothion results in decreased activity of CYP1A1 proteinPMID:20183062
CYP1A1increases expressionEXP 6480464CTDFenitrothion results in increased expression of CYP1A1 mRNAPMID:21298709
CYP1A1decreases activityISOCyp1a1 (Mus musculus)6480464CTDFenitrothion results in decreased activity of CYP1A1 proteinPMID:15620088
CYP1A1increases expressionISOCyp1a1 (Rattus norvegicus)6480464CTDFenitrothion results in increased expression of CYP1A1 mRNAPMID:30639957 PMID:34802538
CYP1A1multiple interactionsISOCyp1a1 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]PMID:30639957 PMID:34802538
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