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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731782
Species: Homo sapiens
RGD Object: Gene
Symbol: HPD
Name: 4-hydroxyphenylpyruvate dioxygenase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HPDaffects expressionEXP 6480464CTDbisphenol A affects the expression of HPD mRNAPMID:30903817
HPDaffects expressionISOHpd (Rattus norvegicus)6480464CTDbisphenol A affects the expression of HPD mRNAPMID:30903817
HPDdecreases expressionISOHpd (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of HPD mRNA; bisphenol A results in decreased expression of HPD proteinPMID:32145629
HPDincreases expressionISOHpd (Mus musculus)6480464CTDbisphenol A results in increased expression of HPD mRNAPMID:30245210
HPDincreases methylationISOHpd (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of HPD genePMID:28505145
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