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Gene: Hpd (4-hydroxyphenylpyruvic acid dioxygenase) Mus musculus
Symbol: Hpd
Name: 4-hydroxyphenylpyruvic acid dioxygenase
RGD ID: 62267
Description: Predicted to have 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to localize to Golgi membrane; endoplasmic reticulum; and endoplasmic reticulum membrane. Is expressed in alimentary system; liver; musculature; and respiratory system. Used to study tyrosinemia type III. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrabromodibenzodioxine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; F; f Alloantigen; F liver antigen; f protein; Fla; Flp; Hp; Hppd; HPPDase; L; Laf
Homo sapiens (human) : HPD (4-hydroxyphenylpyruvate dioxygenase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hpd (4-hydroxyphenylpyruvate dioxygenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hpd (4-hydroxyphenylpyruvate dioxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : HPD (4-hydroxyphenylpyruvate dioxygenase)
Canis lupus familiaris (dog) : HPD (4-hydroxyphenylpyruvate dioxygenase)
Sus scrofa (pig) : HPD (4-hydroxyphenylpyruvate dioxygenase)
Chlorocebus sabaeus (African green monkey) : HPD (4-hydroxyphenylpyruvate dioxygenase)
Heterocephalus glaber (naked mole-rat) : Hpd (4-hydroxyphenylpyruvate dioxygenase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5123,171,807 - 123,182,727 (-)EnsemblGRCm38mm10GRCm38
GRCm385123,171,807 - 123,182,723 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375123,621,816 - 123,632,695 (-)NCBIGRCm37mm9NCBIm37
MGSCv365123,432,425 - 123,443,305 (-)NCBImm8
Celera5120,267,078 - 120,277,955 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hpd
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62267
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.