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Gene: Hpd (4-hydroxyphenylpyruvic acid dioxygenase) Mus musculus
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Symbol: Hpd
Name: 4-hydroxyphenylpyruvic acid dioxygenase
RGD ID: 62267
Description: Predicted to have 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to localize to Golgi membrane; endoplasmic reticulum; and endoplasmic reticulum membrane. Is expressed in alimentary system; liver; musculature; and respiratory system. Used to study tyrosinemia type III. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrabromodibenzodioxine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; F; f Alloantigen; F liver antigen; f protein; Fla; Flp; Hp; Hppd; HPPDase; L; Laf
Orthologs:
Homo sapiens (human) : HPD (4-hydroxyphenylpyruvate dioxygenase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hpd (4-hydroxyphenylpyruvate dioxygenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hpd (4-hydroxyphenylpyruvate dioxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : HPD (4-hydroxyphenylpyruvate dioxygenase)
Canis lupus familiaris (dog) : HPD (4-hydroxyphenylpyruvate dioxygenase)
Sus scrofa (pig) : HPD (4-hydroxyphenylpyruvate dioxygenase)
Chlorocebus sabaeus (African green monkey) : HPD (4-hydroxyphenylpyruvate dioxygenase)
Heterocephalus glaber (naked mole-rat) : Hpd (4-hydroxyphenylpyruvate dioxygenase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl5123,171,807 - 123,182,727 (-)EnsemblGRCm38mm10GRCm38
GRCm385123,171,807 - 123,182,723 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375123,621,816 - 123,632,695 (-)NCBIGRCm37mm9NCBIm37
MGSCv365123,432,425 - 123,443,305 (-)NCBImm8
Celera5120,267,078 - 120,277,955 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hpd
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62267
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.