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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10864
Species: Mus musculus
RGD Object: Gene
Symbol: Ldlr
Name: low density lipoprotein receptor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldlraffects response to substanceEXP 6480464CTDLDLR protein affects the susceptibility to bisphenol APMID:31842455
Ldlrincreases expressionEXP 6480464CTDbisphenol A results in increased expression of LDLR mRNAPMID:23704952 PMID:25270620
Ldlrmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of LDLR mRNA; [LDLR protein affects the susceptibility to bisphenol A] which affects the expression of APOA1 mRNAPMID:31842455 PMID:35739755
Ldlraffects expressionISOLdlr (Rattus norvegicus)6480464CTDbisphenol A affects the expression of LDLR mRNAPMID:30903817
Ldlraffects expressionISOLDLR (Homo sapiens)6480464CTDbisphenol A affects the expression of LDLR mRNAPMID:30903817
Ldlrdecreases expressionISOLdlr (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of LDLR mRNAPMID:30816183
Ldlrdecreases expressionISOLDLR (Homo sapiens)6480464CTDbisphenol A analog results in decreased expression of LDLR mRNAPMID:32387340
Ldlrincreases expressionISOLdlr (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of LDLR mRNA; bisphenol A results in increased expression of LDLR proteinPMID:25181051 PMID:32145629 PMID:32429515
Ldlrincreases expressionISOLDLR (Homo sapiens)6480464CTDbisphenol A results in increased expression of LDLR mRNAPMID:25047013 PMID:28483554 PMID:29275510
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