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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:30563
Term: silicon dioxide
Definition: A silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.
Chemical ID: MESH:D012822
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDSilicon Dioxide results in decreased expression of BCL2 mRNAPMID:33749107
Bcl2multiple interactionsEXP 6480464CTDAsian ginseng inhibits the reaction [Silicon Dioxide results in decreased expression of BCL2 mRNA]PMID:33749107
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDSilicon Dioxide analog results in decreased expression of BCL2 mRNA; Silicon Dioxide analog results in decreased expression of BCL2 proteinPMID:26263183
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDSilicon Dioxide results in decreased expression of BCL2 mRNA; Silicon Dioxide results in decreased expression of BCL2 proteinPMID:21723938 PMID:21766316 PMID:22245848 PMID:25351596 PMID:32061152
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]; CASP1 protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]]PMID:22273745
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDABT-737 inhibits the reaction [Silicon Dioxide promotes the reaction [BCL2 protein binds to BECN1 protein]]; Ascorbic Acid inhibits the reaction [Silicon Dioxide results in decreased expression of BCL2 mRNA]; Ascorbic Acid inhibits the reaction [Silicon Dioxide results in decreased expression of BCL2 protein]; Silicon Dioxide promotes the reaction [BCL2 protein binds to BECN1 protein]PMID:22245848 PMID:32061152
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