GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CDK4 | decreases expression | EXP | | 6480464 | CTD | sodium arsenite results in decreased expression of CDK4 mRNA; sodium arsenite results in decreased expression of CDK4 protein | PMID:20886546 PMID:26878773 | CDK4 | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of CDK4 protein | PMID:21726611 | CDK4 | multiple interactions | EXP | | 6480464 | CTD | 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased expression of CDK4 protein]; JUN protein promotes the reaction [sodium arsenite results in increased expression of CDK4 protein]; MAPK8 protein promotes the reaction [sodium arsenite results in increased expression of CDK4 protein]; sodium arsenite promotes the reaction [CCND1 protein binds to CDK4 protein]; sodium arsenite promotes the reaction [CDK4 protein binds to CDKN1A protein]; sodium arsenite promotes the reaction [CDK4 protein binds to CDKN1B protein]; sodium arsenite results in decreased expression of and results in decreased activity of CDK4 protein | PMID:21726611 PMID:26878773 PMID:29039521 | CDK4 | affects expression | ISO | Cdk4 (Mus musculus) | 6480464 | CTD | sodium arsenite affects the expression of CDK4 mRNA | PMID:16507464 | CDK4 | decreases activity | ISO | Cdk4 (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased activity of CDK4 protein | PMID:11807808 | CDK4 | decreases expression | ISO | Cdk4 (Rattus norvegicus) | 6480464 | CTD | sodium arsenite results in decreased expression of CDK4 mRNA; sodium arsenite results in decreased expression of CDK4 protein | PMID:20598115 PMID:21964460 | CDK4 | decreases expression | ISO | Cdk4 (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of CDK4 protein | PMID:20336670 PMID:27723467 | CDK4 | increases expression | ISO | Cdk4 (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased expression of CDK4 protein | PMID:16507464 | CDK4 | multiple interactions | ISO | Cdk4 (Rattus norvegicus) | 6480464 | CTD | Tretinoin inhibits the reaction [sodium arsenite results in decreased expression of CDK4 mRNA] | PMID:21964460 | CDK4 | multiple interactions | ISO | Cdk4 (Mus musculus) | 6480464 | CTD | Plant Extracts inhibits the reaction [sodium arsenite results in decreased expression of CDK4 protein] | PMID:27723467 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |