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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:29063
Term: L-mimosine
Definition: An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.
Chemical ID: MESH:D008898
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases activityEXP 6480464CTDMimosine results in decreased activity of TNF proteinPMID:15550384
Tnfmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein]PMID:15550384
Tnfdecreases activityISOTNF (Homo sapiens)6480464CTDMimosine results in decreased activity of TNF proteinPMID:15550384
Tnfdecreases activityISOTnf (Rattus norvegicus)6480464CTDMimosine results in decreased activity of TNF proteinPMID:15550384
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein]PMID:15550384
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