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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:28714
Term: S-butyl-DL-homocysteine (S,R)-sulfoximine
Definition: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
Chemical ID: MESH:D019328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTDButhionine Sulfoximine promotes the reaction [cyanoginosin LR results in decreased expression of BCL2 protein]PMID:25410294
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDButhionine Sulfoximine results in decreased expression of BCL2 mRNA; Buthionine Sulfoximine results in decreased expression of BCL2 proteinPMID:17989939 PMID:18552690
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDSodium Selenite promotes the reaction [Buthionine Sulfoximine results in decreased expression of BCL2 mRNA]PMID:17989939
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in increased expression of BCL2 protein]PMID:11341981
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