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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732502
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:28527
Term: rutin
Definition: A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups.
Chemical ID: MESH:D012431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK1decreases phosphorylationEXP 6480464CTDRutin results in decreased phosphorylation of MAPK1 proteinPMID:21756928
MAPK1multiple interactionsEXP 6480464CTDRutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]PMID:19557821 PMID:21756928
MAPK1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTDRutin inhibits the reaction [Acrylamide results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of MAPK1 protein]PMID:22426011 PMID:32864822 PMID:36657526
MAPK1multiple interactionsISOMapk1 (Mus musculus)6480464CTDRutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]PMID:29522708
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