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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10458
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1multiple interactionsEXP 6480464CTD[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNAPMID:21224054
Cyp7a1decreases expressionISOCYP7A1 (Homo sapiens)6480464CTDRifampin results in decreased expression of CYP7A1 mRNAPMID:15629111 PMID:21127053 PMID:22258563 PMID:24259679 PMID:34689256
Cyp7a1multiple interactionsISOCyp7a1 (Rattus norvegicus)6480464CTD[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CYP7A1 proteinPMID:35835356
Cyp7a1multiple interactionsISOCYP7A1 (Homo sapiens)6480464CTD[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CYP7A1 protein; NR1I2 protein promotes the reaction [Rifampin results in decreased expression of CYP7A1 mRNA]PMID:21127053 PMID:35835356
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