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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDresveratrol results in decreased expression of BCL2; resveratrol results in decreased expression of BCL2 mRNAPMID:24092990 PMID:24534837
Bcl2increases expressionEXP 6480464CTDResveratrol results in increased expression of BCL2; Resveratrol results in increased expression of BCL2 proteinPMID:15345477 PMID:20861279 PMID:21111721 PMID:23284668 PMID:23353162 PMID:23747682 PMID:31433112
Bcl2increases phosphorylationEXP 6480464CTDresveratrol results in increased phosphorylation of BCL2 proteinPMID:15345477
Bcl2multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in increased expression of BCL2 protein]; [1-Methyl-4-phenylpyridinium co-treated with Resveratrol] results in increased expression of BCL2 mRNA; [MRS 1191 results in decreased activity of ADORA3 protein] inhibits the reaction [Resveratrol results in increased phosphorylation of BCL2 protein]; [Resveratrol co-treated with Propofol] results in increased expression of BCL2; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [chromium hexavalent ion results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Gallic Acid results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [MIR136 promotes the reaction [Paraquat results in decreased expression of BCL2 protein]]; Resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Oxygen results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]PMID:15345477 PMID:19073162 PMID:19466539 PMID:19723098 PMID:22148982 PMID:23353162 PMID:23833438 PMID:24492640 PMID:25714330 PMID:26054749 PMID:28713934 PMID:31433112 PMID:33587916 PMID:35024197 PMID:35236239
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDResveratrol results in decreased expression of BCL2 mRNA; Resveratrol results in decreased expression of BCL2 proteinPMID:15637762
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTD[Resveratrol results in decreased expression of MTA1 protein] which results in decreased expression of BCL2 protein; Resveratrol analog results in decreased expression of BCL2 protein; Resveratrol results in decreased expression of BCL2; Resveratrol results in decreased expression of BCL2 mRNA; Resveratrol results in decreased expression of BCL2 proteinPMID:12060119 PMID:12632486 PMID:12689943 PMID:12902349 PMID:15633232 PMID:15688415 PMID:16209266 PMID:16490592 PMID:16731767 PMID:17049120 PMID:17164350 PMID:17636462 PMID:19484992 PMID:19631782 PMID:19661309 PMID:19796711 PMID:19810103 PMID:19846903 PMID:20717957 PMID:21209944 PMID:21304978 PMID:21743969 PMID:22301921 PMID:22673012 PMID:23314035 PMID:23359184 PMID:23536519 PMID:23594881 PMID:24331535 PMID:24535223 PMID:25776512 PMID:25896424 PMID:26772155 PMID:26911335 PMID:26969377 PMID:27064016 PMID:29705353
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to resveratrolPMID:11577002 PMID:19631782
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDresveratrol results in increased expression of BCL2 mRNA; resveratrol results in increased expression of BCL2 proteinPMID:18819863 PMID:22878646 PMID:23090186 PMID:23525482 PMID:25116358
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDresveratrol results in increased expression of BCL2 mRNA; resveratrol results in increased expression of BCL2 proteinPMID:17261084 PMID:18592012 PMID:19549761 PMID:21161674
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[Ellagic Acid co-treated with Resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BCL2 mRNA]; [Plant Extracts co-treated with Resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BCL2 mRNA]; Resveratrol affects the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Arginine results in increased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Arginine results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [ERCC6 gene mutant form results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [glyoxylic acid results in decreased expression of BCL2 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]PMID:20103723 PMID:22763982 PMID:24682241 PMID:25440059 PMID:27260466 PMID:34333021 PMID:34423886 PMID:36925030
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[allyl sulfide co-treated with Resveratrol] results in decreased expression of BCL2 mRNA; [Benzo(a)pyrene co-treated with Resveratrol] results in decreased expression of BCL2 mRNA; [Doxorubicin co-treated with Resveratrol] results in decreased expression of BCL2 mRNA; [Doxorubicin co-treated with Resveratrol] results in decreased expression of BCL2 protein; [Resveratrol co-treated with beta-1,3-glucan] results in increased expression of BCL2 mRNA; [Resveratrol co-treated with Glucose] results in increased expression of BCL2 protein; [Resveratrol co-treated with Raloxifene Hydrochloride] results in decreased expression of BCL2 mRNA; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in decreased expression of BCL2 protein]]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in decreased expression of BCL2 protein]; Arsenic Trioxide promotes the reaction [Resveratrol results in decreased expression of BCL2 protein]; BCL2 protein inhibits the reaction [Resveratrol affects the localization of CYCS protein]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [[CASP3 protein results in increased cleavage of aspartyl-glutamyl-valyl-aspartyl-p-nitroanilide] which results in increased chemical synthesis of 4-nitroaniline]]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to CREBBP protein]]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to DAXX protein]]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to SP100 protein]]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to SUMO1 protein]]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to TP53 protein]]; BCL2 protein inhibits the reaction [Resveratrol results in decreased expression of BIRC2 protein]; BCL2 protein inhibits the reaction [Resveratrol results in decreased expression of BIRC3 protein]; BCL2 protein inhibits the reaction [Resveratrol results in decreased expression of CASP3 protein]; BCL2 protein inhibits the reaction [Resveratrol results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Resveratrol results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Resveratrol results in increased cleavage of PARP1 protein]; BCL2 protein inhibits the reaction [Resveratrol results in increased cleavage of PLCG1 protein]; BCL2 protein inhibits the reaction [Resveratrol results in increased degradation of PLCG1 protein]; chelerythrine inhibits the reaction [Resveratrol affects the expression of BCL2 protein]; diphenyleneiodonium inhibits the reaction [Resveratrol affects the expression of BCL2 protein]; MIR21 mRNA inhibits the reaction [Resveratrol results in decreased expression of BCL2 protein]; NQO2 protein promotes the reaction [Resveratrol results in decreased expression of BCL2 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Resveratrol results in increased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [cudraflavone B results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Dopamine results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [MIR21 mRNA results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]; Resveratrol promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; Resveratrol promotes the reaction [Sorafenib results in decreased expression of BCL2 protein]; Resveratrol promotes the reaction [Temozolomide results in decreased expression of BCL2 protein]; Vorinostat inhibits the reaction [BCL2 protein inhibits the reaction [Resveratrol results in increased cleavage of and results in increased activity of CASP3 protein]]; Vorinostat inhibits the reaction [BCL2 protein inhibits the reaction [Resveratrol results in increased cleavage of PARP1 protein]]; Vorinostat inhibits the reaction [BCL2 protein results in decreased susceptibility to Resveratrol]PMID:11577002 PMID:12510025 PMID:17603292 PMID:17690738 PMID:18512326 PMID:19620254 PMID:19631782 PMID:19661309 PMID:21161674 PMID:22530672 PMID:23359184 PMID:23452621 PMID:23881456 PMID:24218232 PMID:24289642 PMID:24535223 PMID:25472572 PMID:25991017 PMID:26772155 PMID:26911335 PMID:26969377 PMID:29705353 PMID:31151226
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