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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620118
Species: Mus musculus
RGD Object: Gene
Symbol: Gsta1
Name: glutathione S-transferase, alpha 1 (Ya)
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta1decreases activityISOGsta5 (Rattus norvegicus)6480464CTDGSTA5 protein results in decreased activity of Aflatoxin B1PMID:11346484
Gsta1decreases expressionISOGSTA5 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of GSTA5 mRNAPMID:21641981
Gsta1decreases response to substanceISOGsta5 (Rattus norvegicus)6480464CTDGSTA5 protein results in decreased susceptibility to Aflatoxin B1PMID:12388831 PMID:8051171 PMID:8625305 PMID:8761455
Gsta1increases expressionISOGsta5 (Rattus norvegicus)6480464CTDAflatoxin B1 results in increased expression of GSTA5 mRNAPMID:14600272 PMID:22545673 PMID:23630614 PMID:25378103
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