GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | INS | decreases expression | EXP | | 6480464 | CTD | Diethylhexyl Phthalate results in decreased expression of INS mRNA; Diethylhexyl Phthalate results in decreased expression of INS protein | PMID:31163220 PMID:35457000 | INS | multiple interactions | EXP | | 6480464 | CTD | Diethylhexyl Phthalate affects the reaction [Glucose results in increased secretion of INS protein]; Diethylhexyl Phthalate promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased secretion of TNFRSF11B protein]; Diethylhexyl Phthalate promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; Diethylhexyl Phthalate promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Diethylhexyl Phthalate promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; Diethylhexyl Phthalate promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]; Diethylhexyl Phthalate promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased secretion of ADIPOQ protein] | PMID:31016361 PMID:34864131 PMID:35457000 | INS | decreases expression | ISO | Ins2 (Rattus norvegicus) | 6480464 | CTD | Diethylhexyl Phthalate results in decreased expression of INS2 mRNA | PMID:25280772 | INS | increases expression | ISO | Ins2 (Mus musculus) | 6480464 | CTD | Diethylhexyl Phthalate results in increased expression of INS2 mRNA | PMID:33484791 | INS | multiple interactions | ISO | Ins2 (Mus musculus) | 6480464 | CTD | [Diethylhexyl Phthalate co-treated with Streptozocin co-treated with Dietary Fats] results in increased expression of INS2 mRNA; [Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in increased expression of INS2 protein; Diethylhexyl Phthalate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS2 mRNA]; Diethylhexyl Phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; Diethylhexyl Phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Diethylhexyl Phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; Diethylhexyl Phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]; Diethylhexyl Phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA alternative form] | PMID:22197818 PMID:33484791 | | ||||||||||||||||||||||
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