Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
2-chloro-4'-methoxychalcone inhibits the reaction [Glucose results in increased expression of TNF mRNA]; 3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide inhibits the reaction [Glucose results in increased expression of TNF mRNA]; 3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide inhibits the reaction [Glucose results in increased secretion of TNF protein]; [Glucose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of TNF protein; CDK9 protein affects the reaction [Glucose results in increased expression of TNF mRNA]; CDK9 protein affects the reaction [Glucose results in increased secretion of TNF protein]; MIR27B mRNA affects the reaction [Glucose results in increased expression of TNF protein]; Plant Extracts inhibits the reaction [TNF protein results in decreased uptake of Glucose]; Silymarin inhibits the reaction [[Glucose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of TNF protein]; SNHG1 affects the reaction [Glucose results in increased expression of TNF mRNA]; SNHG1 affects the reaction [Glucose results in increased expression of TNF protein]; SNHG1 affects the reaction [MIR27B mRNA affects the reaction [Glucose results in increased expression of TNF protein]]
(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of ACADSB mRNA]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; [Glucose co-treated with Lipopolysaccharides] results in decreased expression of TNF protein; [Glucose co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TNF protein; [Glucose co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of PPARG mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of ACADSB mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of PPARA mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of CCL5 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of CXCL5 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NFKB1 mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of PPARD mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of RELA mRNA; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein; [Resveratrol affects the localization of RELA protein] inhibits the reaction [Glucose results in increased expression of TNF mRNA]; [Resveratrol affects the localization of RELA protein] inhibits the reaction [Glucose results in increased expression of TNF protein]; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] inhibits the reaction [Glucose results in increased secretion of INS protein alternative form]; Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased expression of TNF protein]]; asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Captopril inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Catechin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Catechin inhibits the reaction [Glucose results in increased expression of TNF protein]; chromic acid inhibits the reaction [[Glucose co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of TNF protein]; Fenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Fluorometholone inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Fluorometholone inhibits the reaction [Glucose results in increased secretion of TNF protein]; huai qi huang inhibits the reaction [Glucose results in increased expression of TNF mRNA]; lanifibranor affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; lanifibranor affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; lanifibranor affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; lanifibranor inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; lanifibranor inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; lanifibranor inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Luteolin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Luteolin inhibits the reaction [Glucose results in increased expression of TNF protein]; MIR217 mRNA inhibits the reaction [Glucose results in increased secretion of TNF protein]; Phytic Acid inhibits the reaction [Glucose results in increased expression of TNF protein]; Pioglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Pioglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Pioglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Pioglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Pioglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Quercetin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Quercetin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Quercetin inhibits the reaction [Glucose results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Resveratrol inhibits the reaction [Glucose results in increased expression of TNF protein]; Rosiglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Rosiglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; Rosiglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Rosiglitazone affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of ACADSB mRNA]; Rosiglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Rosiglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Rosiglitazone inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; rutecarpine inhibits the reaction [Glucose results in increased expression of TNF mRNA]; rutecarpine inhibits the reaction [Glucose results in increased expression of TNF protein]; Rutin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of TNF protein]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of ELOVL6 mRNA]; saroglitazar affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; saroglitazar inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]; Troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of TNF protein]]; 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Glucose results in increased expression of TNF mRNA]; [Glucose co-treated with IGF2R protein modified form] results in increased expression of TNF protein; [Lipopolysaccharides co-treated with Glucose] results in increased secretion of TNF protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of TNF protein; [TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein]; Atorvastatin inhibits the reaction [TNF protein results in increased oxidation of Glucose]; Calcitriol inhibits the reaction [[Lipopolysaccharides co-treated with Glucose] results in increased secretion of TNF protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of TNF protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Glucose results in increased secretion of TNF protein]; farrerol inhibits the reaction [Glucose results in increased expression of TNF mRNA]; farrerol inhibits the reaction [Glucose results in increased secretion of TNF protein]; Gallic Acid inhibits the reaction [Glucose results in increased secretion of TNF protein]; morroniside inhibits the reaction [Glucose results in increased secretion of TNF protein]; prolinedithiocarbamate inhibits the reaction [Glucose results in increased secretion of TNF protein]; Quercetin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Quercetin inhibits the reaction [Glucose results in increased expression of TNF protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of TNF protein]]; trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of TNF protein]
