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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552009
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2l1
Name: BCL2-like 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of BCL2L1 mRNA; Lipopolysaccharides results in increased expression of BCL2L1 proteinPMID:18789402 PMID:23107598
Bcl2l1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; [Lipopolysaccharides co-treated with EPO protein] results in increased expression of BCL2L1 protein; [TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 mRNA; [TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 protein; Indirubin E804 inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 mRNA]; Lipopolysaccharides promotes the reaction [Indirubin E804 results in decreased expression of BCL2L1 mRNA]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 mRNA]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]PMID:18789402 PMID:23107598 PMID:24453940 PMID:24561306
Bcl2l1decreases expressionISOBcl2l1 (Rattus norvegicus)6480464CTDLipopolysaccharides results in decreased expression of BCL2L1 proteinPMID:31777165
Bcl2l1increases expressionISOBCL2L1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of BCL2L1 mRNAPMID:25725100
Bcl2l1multiple interactionsISOBcl2l1 (Rattus norvegicus)6480464CTDMIR16 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2L1 protein]PMID:31777165
Bcl2l1multiple interactionsISOBCL2L1 (Homo sapiens)6480464CTD(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]PMID:18789402 PMID:25725100
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