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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342674
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGC1Adecreases expressionEXP 6480464CTDQuercetin results in decreased expression of PPARGC1A mRNAPMID:21632981
PPARGC1Aincreases expressionEXP 6480464CTDQuercetin results in increased expression of PPARGC1A mRNAPMID:32530119
PPARGC1Amultiple interactionsEXP 6480464CTDTamoxifen inhibits the reaction [Quercetin results in increased expression of PPARGC1A mRNA]PMID:32530119
PPARGC1Aincreases expressionISOPpargc1a (Mus musculus)6480464CTDQuercetin results in increased expression of PPARGC1A mRNAPMID:19211721
PPARGC1Amultiple interactionsISOPpargc1a (Mus musculus)6480464CTD[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PPARGC1A mRNA; Quercetin affects the reaction [Catechin affects the expression of PPARGC1A mRNA]; Quercetin inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]PMID:18657603 PMID:24586721 PMID:26363153
PPARGC1Amultiple interactionsISOPpargc1a (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [aluminum lactate results in decreased expression of PPARGC1A mRNA]; Quercetin inhibits the reaction [aluminum lactate results in decreased expression of PPARGC1A protein]; Quercetin inhibits the reaction [Vincristine results in decreased expression of PPARGC1A protein]PMID:26493151 PMID:36808657
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