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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734431
Species: Homo sapiens
RGD Object: Gene
Symbol: NFE2L2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:15864
Term: luteolin
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers.
Chemical ID: MESH:D047311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFE2L2multiple interactionsISONfe2l2 (Rattus norvegicus)155882543RGDluteolin inhibits the reaction [ischemia-reperfusion injury increases expression of Nfe2l2 protein in nucleus] 
NFE2L2multiple interactionsEXP 6480464CTD[Luteolin results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; Luteolin inhibits the reaction [decabromobiphenyl ether results in decreased expression of NFE2L2 protein]; Luteolin inhibits the reaction [Irinotecan results in increased expression of NFE2L2 mRNA]; Luteolin promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] affects the localization of NFE2L2 protein]; Luteolin results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 proteinPMID:32407927 PMID:33675858 PMID:34217685 PMID:34699766
NFE2L2increases activityISONfe2l2 (Rattus norvegicus)6480464CTDLuteolin results in increased activity of NFE2L2 proteinPMID:17982879
NFE2L2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTD[Luteolin results in increased activity of NFE2L2 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; Luteolin affects the localization of and results in increased activity of NFE2L2 protein; Luteolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]PMID:17982879 PMID:22864849 PMID:31091348
NFE2L2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDLuteolin promotes the reaction [Rotenone results in increased expression of NFE2L2 mRNA]PMID:30207190
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