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GENE - TERM ANNOTATION REPORT

RGD ID: 736638
Species: Homo sapiens
RGD Object: Gene
Symbol: GLP1R
Name: glucagon like peptide 1 receptor
Acc ID: GO:0007189
Term: adenylate cyclase-activating G protein-coupled receptor signaling pathway
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling.
Definition Source(s): GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GLP1R ISOGlp1r (Rattus norvegicus)9068941RGD PMID:8612565 REF_RGD_ID:1598447
GLP1Rinvolved_inIBAPANTHER:PTN002898432 or Gcgr (Rattus norvegicus) or Glp1r (Rattus norvegicus) or UniProtKB:P43220 or UniProtKB:P47871150520179GO_Central GO_REF:0000033
GLP1Rinvolved_inIEAPANTHER:PTHR45620:SF25150520179TreeGrafter GO_REF:0000118
GLP1Rinvolved_inIDA 150520179UniProt PMID:28514449

PMID:28514449
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