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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTDTestosterone binds to ESR1 proteinPMID:19913605
ESR1decreases expressionEXP 6480464CTDTestosterone results in decreased expression of ESR1 mRNAPMID:33728745
ESR1increases activityEXP 6480464CTDTestosterone results in increased activity of ESR1 proteinPMID:22562034
ESR1multiple interactionsEXP 6480464CTD[Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [ESR1 protein binds to TRAF6 protein]; ESR1 protein promotes the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA]; Fulvestrant inhibits the reaction [Testosterone results in increased activity of ESR1 protein]; Testosterone binds to and results in increased activity of ESR1 proteinPMID:12676605 PMID:17823853 PMID:22562034 PMID:29162470 PMID:29625166
ESR1decreases abundanceISOEsr1 (Mus musculus)6480464CTDESR1 protein results in decreased abundance of TestosteronePMID:20833731
ESR1decreases expressionISOEsr1 (Mus musculus)6480464CTDTestosterone results in decreased expression of ESR1 mRNA; Testosterone results in decreased expression of ESR1 proteinPMID:15916834 PMID:20403060 PMID:20600201 PMID:20844152
ESR1increases expressionISOEsr1 (Mus musculus)6480464CTDTestosterone results in increased expression of ESR1 mRNA alternative formPMID:12399412
ESR1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDTestosterone results in increased expression of ESR1 mRNA; Testosterone results in increased expression of ESR1 proteinPMID:15917159 PMID:23500659 PMID:26492952 PMID:27866977
ESR1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTDFinasteride inhibits the reaction [Testosterone results in increased expression of ESR1 protein]; Metformin inhibits the reaction [Testosterone results in increased expression of ESR1 mRNA]; Qing Ye Dan inhibits the reaction [Testosterone results in increased expression of ESR1 protein]; Silymarin inhibits the reaction [Testosterone results in increased expression of ESR1 protein]; swertiamarin inhibits the reaction [Testosterone results in increased expression of ESR1 protein]PMID:23500659 PMID:26492952 PMID:27866977
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