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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736021
Species: Homo sapiens
RGD Object: Gene
Symbol: APP
Name: amyloid beta precursor protein
Acc ID: CHEBI:5130
Term: flurbiprofen
Definition: A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Chemical ID: MESH:D005480
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APPdecreases secretionEXP 6480464CTDFlurbiprofen results in decreased secretion of APP proteinPMID:17292621 PMID:19659691
APPmultiple interactionsEXP 6480464CTDalitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein]; Flurbiprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of APP protein]; RXRA protein promotes the reaction [Flurbiprofen results in decreased secretion of APP protein]PMID:19659691
APPaffects cleavageISOApp (Mus musculus)6480464CTDFlurbiprofen affects the cleavage of APP proteinPMID:14690522
APPmultiple interactionsISOApp (Rattus norvegicus)6480464CTDFlurbiprofen inhibits the reaction [APP protein results in increased uptake of Calcium]PMID:18648507
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