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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:104736480464CTDMelatonin results in increased expression of NQO1 protein

PMID:25288107
increases expressionISORGD:25036480464CTDMelatonin results in increased expression of NQO1 protein

PMID:20433640
multiple interactionsISORGD:104736480464CTDMelatonin affects the reaction [manganese chloride affects the expression of NQO1 protein], Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]], Melatonin inhibits the reaction [manganese chloride results in decreased expression of NQO1 protein]

PMID:24969583, PMID:25288107, PMID:27871981
multiple interactionsISORGD:25036480464CTD[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA, Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]

PMID:20033131, PMID:20433640
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.