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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735594
Species: Homo sapiens
RGD Object: Gene
Symbol: LDLR
Name: low density lipoprotein receptor
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LDLRincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of LDLR mRNA; Lipopolysaccharides results in increased expression of LDLR proteinPMID:33677747
LDLRmultiple interactionsEXP 6480464CTD[NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of LDLR mRNA; MIR590 mRNA inhibits the reaction [Lipopolysaccharides results in increased expression of LDLR mRNA]; MIR590 mRNA inhibits the reaction [Lipopolysaccharides results in increased expression of LDLR protein]; UBE2I protein inhibits the reaction [Lipopolysaccharides results in increased expression of LDLR protein]PMID:33677747 PMID:35877022
LDLRdecreases expressionISOLdlr (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of LDLR mRNA; Lipopolysaccharides results in decreased expression of LDLR proteinPMID:18638454
LDLRincreases expressionISOLdlr (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of LDLR mRNAPMID:12057914
LDLRincreases expressionISOLdlr (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased expression of LDLR proteinPMID:33677747
LDLRmultiple interactionsISOLdlr (Rattus norvegicus)6480464CTDethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Lipopolysaccharides results in increased expression of LDLR protein]; SREBF2 protein affects the reaction [Lipopolysaccharides results in increased expression of LDLR protein]PMID:33677747
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