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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735591
Species: Homo sapiens
RGD Object: Gene
Symbol: IL10
Name: interleukin 10
Acc ID: CHEBI:3374
Term: capsaicin
Definition: A capsaicinoid that has formula C18H27NO3.
Chemical ID: MESH:D002211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL10increases expressionISOIl10 (Rattus norvegicus)6480464CTDCapsaicin results in increased expression of IL10 mRNA; Capsaicin results in increased expression of IL10 proteinPMID:15502055 PMID:18460982 PMID:22150557
IL10multiple interactionsISOIl10 (Mus musculus)6480464CTDCapsaicin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]; TRPV1 gene mutant form inhibits the reaction [Capsaicin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]]PMID:19878665
IL10multiple interactionsISOIl10 (Rattus norvegicus)6480464CTD[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL10 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL10 protein]; Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL10 protein]PMID:22150557
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