Gene Chemical Interaction Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	735440
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	NFKBIA
Name:	NFKB inhibitor alpha

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
NFKBIA	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of NFKBIA mRNA; Cisplatin results in increased expression of NFKBIA protein	PMID:27594783 PMID:32762018
NFKBIA	increases phosphorylation	EXP		6480464	CTD	Cisplatin results in increased phosphorylation of NFKBIA protein	PMID:29471006
NFKBIA	multiple interactions	EXP		6480464	CTD	astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]	PMID:29471006
NFKBIA	affects response to substance	ISO	Nfkbia (Mus musculus)	6480464	CTD	NFKBIA protein affects the susceptibility to Cisplatin	PMID:15746559
NFKBIA	decreases expression	ISO	Nfkbia (Rattus norvegicus)	6480464	CTD	Cisplatin results in decreased expression of NFKBIA mRNA; Cisplatin results in decreased expression of NFKBIA protein	PMID:18172885 PMID:32418911 PMID:33522649
NFKBIA	increases degradation	ISO	Nfkbia (Mus musculus)	6480464	CTD	Cisplatin results in increased degradation of NFKBIA protein	PMID:21526214
NFKBIA	increases expression	ISO	Nfkbia (Mus musculus)	6480464	CTD	Cisplatin results in increased expression of NFKBIA mRNA	PMID:21151649 PMID:26546572
NFKBIA	increases phosphorylation	ISO	Nfkbia (Mus musculus)	6480464	CTD	Cisplatin results in increased phosphorylation of NFKBIA protein	PMID:32991863
NFKBIA	multiple interactions	ISO	Nfkbia (Mus musculus)	6480464	CTD	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of NFKBIA mRNA]; [Cisplatin promotes the reaction [Lipopolysaccharides binds to TLR4 protein]] which results in increased phosphorylation of NFKBIA protein; anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]; Cisplatin promotes the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Rosmarinic Acid inhibits the reaction [Cisplatin results in increased degradation of NFKBIA protein]	PMID:21148032 PMID:21526214 PMID:23103562 PMID:26546572 PMID:32991863
NFKBIA	multiple interactions	ISO	Nfkbia (Rattus norvegicus)	6480464	CTD	7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein]; Cisplatin results in increased phosphorylation of and results in increased degradation of NFKBIA protein; fisetin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Omeprazole inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein]	PMID:25184746 PMID:32418911 PMID:33522649

Go Back to source page

Continue to Ontology report