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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734431
Species: Homo sapiens
RGD Object: Gene
Symbol: NFE2L2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:2825
Term: aristolochic acid A
Definition: An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Chemical ID: MESH:C000228
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFE2L2decreases expressionISONfe2l2 (Rattus norvegicus)6480464CTDaristolochic acid I results in decreased expression of NFE2L2 mRNA; aristolochic acid I results in decreased expression of NFE2L2 proteinPMID:36037877
NFE2L2decreases expressionISONfe2l2 (Mus musculus)6480464CTDaristolochic acid I results in decreased expression of NFE2L2 mRNAPMID:24530882
NFE2L2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 protein]PMID:36037877
NFE2L2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDaristolochic acid I results in decreased expression of and affects the localization of NFE2L2 protein; bardoxolone methyl inhibits the reaction [aristolochic acid I results in decreased expression of and affects the localization of NFE2L2 protein]; bardoxolone methyl inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 mRNA]PMID:24530882
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