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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aristolochic acid A
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Accession:CHEBI:2825 term browser browse the term
Definition:An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Synonyms:exact_synonym: 8-methoxy-6-nitro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
 related_synonym: 3,4-methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid;   8-methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid;   8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid;   AAA;   Aristolochic acid;   Aristolochic acid I;   Formula=C17H11NO7;   InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20);   InChIKey=BBFQZRXNYIEMAW-UHFFFAOYSA-N;   SMILES=COc1cccc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C(O)=O;   aristolochin
 xref: CAS:313-67-7;   KEGG:C08469;   KNApSAcK:C00001526;   KNApSAcK:C00027516;   LINCS:LSM-2373
 xref_mesh: MESH:C000228
 xref: PMID:21558304;   PMID:21719716;   PMID:22071594;   PMID:22118289;   PMID:22126455;   PMID:22245565;   PMID:22373701;   Reaxys:345159;   Wikipedia:Aristolochic_acid


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    Path 1
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      CHEBI ontology 26506
        role 26329
          biological role 26308
            biochemical role 25520
              metabolite 25457
                aristolochic acid A 7388
                  aristoloterpenate-I 0
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      CHEBI ontology 26506
        subatomic particle 26482
          composite particle 26482
            hadron 26482
              baryon 26482
                nucleon 26482
                  atomic nucleus 26482
                    atom 26482
                      main group element atom 26220
                        p-block element atom 26220
                          carbon group element atom 25665
                            carbon atom 25627
                              organic molecular entity 25627
                                heteroorganic entity 25013
                                  organochalcogen compound 24607
                                    organooxygen compound 24203
                                      carbon oxoacid 22826
                                        carboxylic acid 22808
                                          monocarboxylic acid 21790
                                            aristolochic acids 7422
                                              aristolochic acid A 7388
                                                aristoloterpenate-I 0
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