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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:43064
Term: hydroxyflutamide
Definition: An anilide that has formula C11H11F3N2O4.
Chemical ID: MESH:C014290
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1affects phosphorylationISOMAPK1 (Homo sapiens)6480464CTDhydroxyflutamide affects the phosphorylation of MAPK1 proteinPMID:28163245
Mapk1increases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTDhydroxyflutamide results in increased phosphorylation of MAPK1 proteinPMID:26437446
Mapk1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [hydroxyflutamide results in increased phosphorylation of MAPK1 protein]; hydroxyflutamide promotes the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]PMID:26437446
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDhydroxyflutamide inhibits the reaction [Testosterone affects the phosphorylation of MAPK1 protein]PMID:28163245
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