GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fgf21 | affects expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of FGF21 mRNA | PMID:21570461 PMID:26377647 PMID:28922406 | Fgf21 | decreases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of FGF21 mRNA | PMID:19770486 PMID:27226639 | Fgf21 | decreases response to substance | EXP | | 6480464 | CTD | FGF21 protein results in decreased susceptibility to Tetrachlorodibenzodioxin | PMID:24769090 | Fgf21 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA; Tetrachlorodibenzodioxin results in increased expression of FGF21 protein | PMID:21846477 PMID:24769090 PMID:26290441 PMID:27562557 | Fgf21 | multiple interactions | EXP | | 6480464 | CTD | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of FGF21 mRNA; AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA]; AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 protein]; Diethylhexyl Phthalate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA]; Diethylhexyl Phthalate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 protein]; N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]]; Tetrachlorodibenzodioxin inhibits the reaction [Glucose deficiency results in increased expression of FGF21 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to FGF21 promoter]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FGF21 promoter]; Tetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in increased expression of FGF21 mRNA]; TIPARP gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA] | PMID:21846477 PMID:24769090 PMID:25975270 PMID:27226639 PMID:34129049 | Fgf21 | affects expression | ISO | Fgf21 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of FGF21 mRNA | PMID:22298810 | Fgf21 | decreases expression | ISO | Fgf21 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of FGF21 mRNA | PMID:21724226 | Fgf21 | increases expression | ISO | FGF21 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA | PMID:24769090 | Fgf21 | multiple interactions | ISO | FGF21 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin inhibits the reaction [Glucose results in increased expression of FGF21 mRNA] | PMID:27226639 | | ||||||||||||||||||||||
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