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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731542
Species: Homo sapiens
RGD Object: Gene
Symbol: NOX4
Name: NADPH oxidase 4
Acc ID: CHEBI:16494
Term: lipoic acid
Definition: A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
Chemical ID: MESH:D008063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOX4multiple interactionsISONox4 (Rattus norvegicus)6480464CTDacetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]PMID:29760339
NOX4multiple interactionsISONox4 (Mus musculus)6480464CTDThioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]PMID:35187969
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