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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3decreases activityISOCasp3 (Rattus norvegicus)2311460RGDtert-butylhydroperoxide decreases activity of Casp3 protein in hepatocyte cytosol 
CASP3decreases expressionEXP 6480464CTDtert-Butylhydroperoxide results in decreased expression of CASP3 proteinPMID:26102008 PMID:28733231
CASP3increases activityEXP 6480464CTDtert-Butylhydroperoxide results in increased activity of CASP3 proteinPMID:12406338 PMID:15611089 PMID:17419000 PMID:28025122
CASP3increases cleavageEXP 6480464CTDtert-Butylhydroperoxide results in increased cleavage of CASP3 proteinPMID:27511913
CASP3increases expressionEXP 6480464CTDtert-Butylhydroperoxide results in increased expression of CASP3 protein; tert-Butylhydroperoxide results in increased expression of CASP3 protein modified formPMID:20847119 PMID:28063877
CASP3multiple interactionsEXP 6480464CTD1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CASP3 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP3 mRNA; acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; Antineoplastic Agents, Immunological inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP3 mRNA]; Drugs, Chinese Herbal inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CASP3 protein]; GPX4 protein inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; KN 93 inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; LY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of CASP3 protein modified form]; MCL1 protein inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP3 mRNA]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; nectandrin-B inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; PAFAH2 protein inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; puag-haad inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CASP3 protein]; rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]PMID:12406338 PMID:15496407 PMID:15611089 PMID:17419000 PMID:26102008 PMID:27511913 PMID:28025122 PMID:28063877 PMID:28733231 PMID:35690295
CASP3increases activityISOCasp3 (Mus musculus)6480464CTDtert-Butylhydroperoxide results in increased activity of CASP3 proteinPMID:15496407 PMID:19647727
CASP3increases cleavageISOCasp3 (Mus musculus)6480464CTDtert-Butylhydroperoxide results in increased cleavage of CASP3 proteinPMID:16753784
CASP3increases cleavageISOCasp3 (Rattus norvegicus)6480464CTDtert-Butylhydroperoxide results in increased cleavage of CASP3 proteinPMID:15569404 PMID:15877105 PMID:26989860
CASP3increases expressionISOCasp3 (Rattus norvegicus)6480464CTDtert-Butylhydroperoxide results in increased expression of CASP3 proteinPMID:15877105
CASP3multiple interactionsISOCasp3 (Mus musculus)6480464CTDcaffeoylquinic acid analog inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; Catechin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Drugs, Chinese Herbal inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; tert-Butylhydroperoxide results in increased expression of and results in increased cleavage of CASP3 proteinPMID:16753784 PMID:19647727 PMID:20510348
CASP3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTDacadesine inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; Silymarin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]PMID:15569404 PMID:19772912 PMID:26989860
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