GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NFKB1 | increases activity | EXP | | 6480464 | CTD | Nicotine results in increased activity of NFKB1 protein | PMID:16598845 | NFKB1 | increases expression | EXP | | 6480464 | CTD | Nicotine results in increased expression of NFKB1 mRNA | PMID:16598845 | NFKB1 | multiple interactions | EXP | | 6480464 | CTD | Vitamin K 3 inhibits the reaction [Nicotine results in increased activity of NFKB1 protein] | PMID:16598845 | NFKB1 | decreases expression | ISO | Nfkb1 (Mus musculus) | 6480464 | CTD | Nicotine results in decreased expression of NFKB1 mRNA; Nicotine results in decreased expression of NFKB1 protein | PMID:17135361 | NFKB1 | multiple interactions | ISO | Nfkb1 (Rattus norvegicus) | 6480464 | CTD | Mecamylamine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]] | PMID:27984197 | | ||||||||||||||||||||||
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