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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70502
Species: Homo sapiens
RGD Object: Gene
Symbol: TP53
Name: tumor protein p53
Acc ID: CHEBI:63933
Term: Aroclor 1254
Definition: A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).
Chemical ID: MESH:D020111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TP53increases expressionISOTrp53 (Mus musculus)6480464CTDChlorodiphenyl (54% Chlorine) results in increased expression of TRP53 mRNAPMID:25113976
TP53increases expressionISOTp53 (Rattus norvegicus)6480464CTDChlorodiphenyl (54% Chlorine) results in increased expression of TP53 proteinPMID:35822628
TP53multiple interactionsISOTp53 (Rattus norvegicus)6480464CTD2-(1',2',3',4'-tetrahydroxybutyl)thiazolidine-4-carboxylic acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of TP53 protein]PMID:35822628
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