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GENE - TERM ANNOTATION REPORT

RGD ID: 69139
Species: Homo sapiens
RGD Object: Gene
Symbol: NPPB
Name: natriuretic peptide B
Acc ID: DOID:9003936
Term: Cardiomegaly
Definition: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Definition Source(s): MESH:D006332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NPPB ISONppb (Mus musculus)401940178RGDmRNA:decreased expression:heart (mouse) 
NPPB ISONppb (Rattus norvegicus)1642206RGDassociated with Hypertension;mRNA:increased expression:heart 
NPPBamelioratesISONppb (Mus musculus)11252017RGD  
NPPBtreatmentISONppb (Rattus norvegicus)7297051RGD  
NPPB EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:15942707 PMID:15969258 PMID:18056528 PMID:21565836
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