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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69139
Species: Homo sapiens
RGD Object: Gene
Symbol: NPPB
Name: natriuretic peptide B
Acc ID: CHEBI:6904
Term: metoprolol
Definition: A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Chemical ID: MESH:D008790
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NPPBdecreases expressionISONppb (Rattus norvegicus)6480464CTDMetoprolol results in decreased expression of NPPB mRNA; Metoprolol results in decreased expression of NPPB proteinPMID:11181074 PMID:20353484 PMID:30310171
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