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ONTOLOGY REPORT - ANNOTATIONS


Term:metoprolol
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Accession:CHEBI:6904 term browser browse the term
Definition:A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Synonyms:exact_synonym: 3-[4-(2-methoxyethyl)phenoxy]-1-(propan-2-ylamino)propan-2-ol
 related_synonym: (RS)-Metoprolol;   1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol;   Formula=C15H25NO3;   InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3;   InChIKey=IUBSYMUCCVWXPE-UHFFFAOYSA-N;   SMILES=COCCc1ccc(OCC(O)CNC(C)C)cc1
 xref: CAS:37350-58-6 "ChemIDplus";   CAS:37350-58-6 "KEGG COMPOUND";   CAS:51384-51-1 "ChemIDplus";   CAS:51384-51-1 "KEGG COMPOUND";   DrugBank:DB00264;   Drug_Central:1786 "DrugCentral";   HMDB:HMDB0001932;   KEGG:C07202;   KEGG:D02358;   LINCS:LSM-1259
 xref_mesh: MESH:D008790
 xref: PMID:15140634 "Europe PMC";   PMID:15797646 "Europe PMC";   PMID:24025984 "Europe PMC";   Reaxys:1117585 "Reaxys";   Wikipedia:Metoprolol


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metoprolol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACE angiotensin I converting enzyme JBrowse link 17 63,477,061 63,498,373 RGD:6480464
G ADRA2C adrenoceptor alpha 2C JBrowse link 4 3,766,385 3,768,526 RGD:6480464
G ADRB1 adrenoceptor beta 1 JBrowse link 10 114,043,866 114,046,904 RGD:6480464
G ADRB2 adrenoceptor beta 2 JBrowse link 5 148,826,593 148,828,634 RGD:6480464
G ADRB3 adrenoceptor beta 3 JBrowse link 8 37,962,990 37,966,599 RGD:6480464
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6480464
G ARRB1 arrestin beta 1 JBrowse link 11 75,260,122 75,351,662 RGD:6480464
G ARRB2 arrestin beta 2 JBrowse link 17 4,710,619 4,721,500 RGD:6480464
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 110,281,247 110,351,093 RGD:6480464
G BCL2L1 BCL2 like 1 JBrowse link 20 31,664,452 31,723,963 RGD:6480464
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6480464
G CASP9 caspase 9 JBrowse link 1 15,491,401 15,524,912 RGD:6480464
G CCN2 cellular communication network factor 2 JBrowse link 6 131,948,176 131,951,372 RGD:6480464
G COL1A1 collagen type I alpha 1 chain JBrowse link 17 50,184,096 50,201,649 RGD:6480464
G COL3A1 collagen type III alpha 1 chain JBrowse link 2 188,974,373 189,012,746 RGD:6480464
G CPT1A carnitine palmitoyltransferase 1A JBrowse link 11 68,754,620 68,844,410 RGD:6480464
G CPT1B carnitine palmitoyltransferase 1B JBrowse link 22 50,568,861 50,578,612 RGD:6480464
G CYB5A cytochrome b5 type A JBrowse link 18 74,250,846 74,291,980 RGD:6480464
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 JBrowse link 22 42,126,499 42,130,810 RGD:6480464
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 JBrowse link 7 99,756,967 99,784,184 RGD:6480464
G ECE1 endothelin converting enzyme 1 JBrowse link 1 21,217,250 21,345,504 RGD:6480464
G EDN1 endothelin 1 JBrowse link 6 12,256,463 12,297,194 RGD:6480464
G FKBP1B FKBP prolyl isomerase 1B JBrowse link 2 24,033,205 24,067,743 RGD:6480464
G FOS Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 14 75,278,828 75,282,230 RGD:6480464
G FOXO3 forkhead box O3 JBrowse link 6 108,559,825 108,684,774 RGD:6480464
G G6PD glucose-6-phosphate dehydrogenase JBrowse link X 154,531,390 154,547,569 RGD:6480464
G GATA4 GATA binding protein 4 JBrowse link 8 11,676,931 11,760,002 RGD:6480464
G GJA1 gap junction protein alpha 1 JBrowse link 6 121,435,646 121,449,727 RGD:6480464
G GRK4 G protein-coupled receptor kinase 4 JBrowse link 4 2,963,504 3,040,760 RGD:6480464
G GRK5 G protein-coupled receptor kinase 5 JBrowse link 10 119,207,571 119,459,745 RGD:6480464
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:6480464
G IL1A interleukin 1 alpha JBrowse link 2 112,773,925 112,784,493 RGD:6480464
G IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:6480464
G JPH2 junctophilin 2 JBrowse link 20 44,111,697 44,187,946 RGD:6480464
G JUN Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 1 58,780,791 58,784,047 RGD:6480464
G JUND JunD proto-oncogene, AP-1 transcription factor subunit JBrowse link 19 18,279,694 18,281,622 RGD:6480464
G KCNH2 potassium voltage-gated channel subfamily H member 2 JBrowse link 7 150,944,956 150,978,321 RGD:6480464
G MEF2A myocyte enhancer factor 2A JBrowse link 15 99,565,417 99,716,488 RGD:6480464
G MIR190A microRNA 190a JBrowse link 15 62,823,957 62,824,041 RGD:6480464
G MMP2 matrix metallopeptidase 2 JBrowse link 16 55,478,830 55,506,691 RGD:6480464
G MMP9 matrix metallopeptidase 9 JBrowse link 20 46,008,908 46,016,561 RGD:6480464
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 8 127,735,434 127,742,951 RGD:6480464
G MYH7 myosin heavy chain 7 JBrowse link 14 23,412,740 23,435,677 RGD:6480464
G NFATC4 nuclear factor of activated T cells 4 JBrowse link 14 24,366,911 24,379,604 RGD:6480464
G NOS1 nitric oxide synthase 1 JBrowse link 12 117,208,142 117,361,802 RGD:6480464
G NOS2 nitric oxide synthase 2 JBrowse link 17 27,756,766 27,800,529 RGD:6480464
G NOS3 nitric oxide synthase 3 JBrowse link 7 150,991,017 151,014,588 RGD:6480464
G NPPA natriuretic peptide A JBrowse link 1 11,845,709 11,847,783 RGD:6480464
G NPPB natriuretic peptide B JBrowse link 1 11,857,464 11,858,945 RGD:6480464
G NR1I3 nuclear receptor subfamily 1 group I member 3 JBrowse link 1 161,229,666 161,238,623 RGD:6480464
G ODC1 ornithine decarboxylase 1 JBrowse link 2 10,439,968 10,448,327 RGD:6480464
G PENK proenkephalin JBrowse link 8 56,440,957 56,446,641 RGD:6480464
G PPARA peroxisome proliferator activated receptor alpha JBrowse link 22 46,150,526 46,243,756 RGD:6480464
G PPARGC1A PPARG coactivator 1 alpha JBrowse link 4 23,792,021 24,472,905 RGD:6480464
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:6480464
G REN renin JBrowse link 1 204,154,819 204,166,337 RGD:6480464
G RPS6KB1 ribosomal protein S6 kinase B1 JBrowse link 17 59,893,046 59,950,574 RGD:6480464
G RYR2 ryanodine receptor 2 JBrowse link 1 237,042,184 237,833,988 RGD:6480464
G SGCD sarcoglycan delta JBrowse link 5 155,728,636 156,767,788 RGD:6480464
G SLC22A1 solute carrier family 22 member 1 JBrowse link 6 160,121,808 160,160,590 RGD:6480464
G SLC22A2 solute carrier family 22 member 2 JBrowse link 6 160,216,755 160,258,821 RGD:6480464
G SPN sialophorin JBrowse link 16 29,662,950 29,670,876 RGD:6480464
G TGFB1 transforming growth factor beta 1 JBrowse link 19 41,330,323 41,353,922 RGD:6480464
G THBS1 thrombospondin 1 JBrowse link 15 39,581,079 39,599,466 RGD:6480464
G THBS4 thrombospondin 4 JBrowse link 5 79,991,296 80,083,753 RGD:6480464
G TIMP2 TIMP metallopeptidase inhibitor 2 JBrowse link 17 78,852,977 78,925,387 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464
G USF2 upstream transcription factor 2, c-fos interacting JBrowse link 19 35,268,962 35,279,821 RGD:6480464
G VEGFA vascular endothelial growth factor A JBrowse link 6 43,770,209 43,786,487 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23673
    role 23561
      biological role 23522
        xenobiotic 19174
          metoprolol 69
Path 2
Term Annotations click to browse term
  CHEBI ontology 23673
    subatomic particle 23620
      composite particle 23620
        hadron 23620
          baryon 23620
            nucleon 23620
              atomic nucleus 23620
                atom 23620
                  main group element atom 23437
                    main group molecular entity 23437
                      s-block molecular entity 22611
                        hydrogen molecular entity 22393
                          hydrides 20497
                            inorganic hydride 18711
                              pnictogen hydride 18669
                                nitrogen hydride 18359
                                  azane 18211
                                    ammonia 18208
                                      organic amino compound 18207
                                        amino alcohol 867
                                          propanolamine 165
                                            metoprolol 69
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.