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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionEXP 6480464CTDTamoxifen results in increased expression of TGFB1 mRNAPMID:19453300
Tgfb1multiple interactionsEXP 6480464CTDTamoxifen inhibits the reaction [allyl alcohol results in increased expression of TGFB1 mRNA]PMID:18564211
Tgfb1decreases expressionISOTgfb1 (Mus musculus)6480464CTDTamoxifen results in decreased expression of TGFB1 mRNAPMID:19279558
Tgfb1decreases secretionISOTGFB1 (Homo sapiens)6480464CTDTamoxifen results in decreased secretion of TGFB1 proteinPMID:8653321
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTD[Tamoxifen results in increased expression of TGFB1 protein] which results in increased expression of FASLG mRNA; [Tamoxifen results in increased expression of TGFB1 protein] which results in increased expression of GZMB mRNA; [Tamoxifen results in increased expression of TGFB1 protein] which results in increased expression of PRF1 mRNA; Tamoxifen results in increased expression of TGFB1 proteinPMID:20145137
Tgfb1increases secretionISOTGFB1 (Homo sapiens)6480464CTDTamoxifen results in increased secretion of TGFB1 proteinPMID:17098229
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTD[Tretinoin co-treated with Tamoxifen] results in increased secretion of TGFB1 protein; TGFB1 protein promotes the reaction [Tamoxifen results in increased expression of FOXP3 mRNA]PMID:17098229 PMID:20145137
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