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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionEXP 6480464CTDpirinixic acid results in increased expression of TGFB1 mRNAPMID:19782605
Tgfb1multiple interactionsEXP 6480464CTDpirinixic acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]PMID:15474484
Tgfb1decreases expressionISOTgfb1 (Mus musculus)6480464CTDpirinixic acid results in decreased expression of TGFB1 mRNAPMID:20059764
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDpirinixic acid inhibits the reaction [Hydrogen Peroxide results in increased expression of TGFB1 mRNA]; pirinixic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]PMID:12573136 PMID:19429239
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDPPARA protein promotes the reaction [pirinixic acid results in decreased expression of TGFB1 mRNA]PMID:20059764
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