GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tgfb1 | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of TGFB1 mRNA; sodium arsenite results in increased expression of TGFB1 protein | PMID:20371363 PMID:24497207 PMID:27174133 PMID:32593899 PMID:34251737 PMID:34673086 | Tgfb1 | multiple interactions | EXP | | 6480464 | CTD | coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; Ginkgo biloba extract inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein]; naringin inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; p-coumaric acid inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; Quercetin analog inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein] | PMID:20371363 PMID:24497207 PMID:27174133 PMID:34251737 | Tgfb1 | affects expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | sodium arsenite affects the expression of TGFB1 mRNA | PMID:28206643 | Tgfb1 | decreases expression | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in decreased expression of TGFB1 mRNA | PMID:19349368 | Tgfb1 | decreases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of TGFB1 mRNA | PMID:36435854 | Tgfb1 | increases expression | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of TGFB1 mRNA; sodium arsenite results in increased expression of TGFB1 protein | PMID:30090515 PMID:30191986 PMID:35142421 PMID:35850069 | Tgfb1 | increases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased expression of TGFB1 mRNA; sodium arsenite results in increased expression of TGFB1 protein | PMID:17003472 PMID:21134390 PMID:21911445 PMID:23732083 PMID:26151952 PMID:34272803 | Tgfb1 | increases secretion | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased secretion of TGFB1 protein | PMID:33241020 | Tgfb1 | multiple interactions | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein]; [sodium arsenite affects the acetylation of H3-4 protein] which affects the methylation of TGFB1 promoter; [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of TGFB1 mRNA; ERRFI1 protein inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein]; HSPA5 protein affects the reaction [sodium arsenite results in increased secretion of TGFB1 protein]; HTS 466284 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; HTS 466284 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein]; oxymatrine inhibits the reaction [sodium arsenite results in increased secretion of TGFB1 protein]; Pertussis Toxin inhibits the reaction [sodium arsenite results in decreased expression of TGFB1 mRNA]; RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein]; TGFB1 protein inhibits the reaction [sodium arsenite results in decreased expression of BCL2 mRNA]; TGFB1 protein inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of BAX mRNA]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of BAX protein]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CASP3 protein modified form]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CASP3 protein]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CASP9 protein modified form]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CASP9 protein]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CYCS mRNA]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of CYCS protein]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of MAPK1 mRNA]; TGFB1 protein promotes the reaction [sodium arsenite results in increased expression of TGFB1 mRNA] | PMID:18448484 PMID:19349368 PMID:23192986 PMID:33241020 PMID:35142421 PMID:35850069 | Tgfb1 | multiple interactions | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of TGFB1 mRNA; Curcumin affects the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; IFNG protein inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein]; TGFB1 protein inhibits the reaction [sodium arsenite results in increased expression of ABCC1 protein] | PMID:17003472 PMID:33148380 PMID:34272803 | | ||||||||||||||||||||||
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