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GENE - TERM ANNOTATION REPORT

RGD ID: 69008
Species: Homo sapiens
RGD Object: Gene
Symbol: IL13
Name: interleukin 13
Acc ID: DOID:2841
Term: asthma
Definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. (DO)
Definition Source(s): http://www.nhlbi.nih.gov/health/dci/Diseases/Asthma/Asthma_WhatIs.html "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK430901/ "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK7223/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL13 IAGP 4145776RGDDNA:polymorphism: :c. 2044G>A (human) 
IL13 IAGP 4146241RGDDNA:SNP: :c. -646A>G (human) 
IL13 IAGP 4892639RGDDNA:polymorphism: :-1512A>C, -1112C>T, 2044G>A (human) 
IL13 IAGP 8549509RGDassociated with Dermatitis, Atopic;DNA, protein:SNP, increased expression:promoter, serum:-1112C>T (human) 
IL13no_associationIAGP 4763761RGDDNA:polymorphism:cds:p.R130Q (human) 
IL13severityIAGP 4145593RGDDNA:polymorphism: :c.-1055C>T (human) 
IL13susceptibilityIAGP 4145534RGDDNA:polymorphisms: :rs20541, rs1295685(human) 
IL13susceptibilityIAGP 4145601RGDDNA:polymorphisms:promoters,exon4: rs1881457, rs1800925, rs20541 (human) 
IL13susceptibilityIAGP 4145775RGDDNA:polymorphism: :c. 1923C>T (human) 
IL13susceptibilityIAGP 4220633RGDDNA:polymorphism:promoter:c. -1055C>T (human) 
IL13susceptibilityIAGP 4321828RGDDNA:polymorphism: :p. R110Q (human) 
IL13susceptibilityIAGP 4765128RGDDNA:polymorphism:3'utr:c.4738G>A (human) 
IL13severityIEP 4145777RGDprotein:increased expression:sputum 
IL13severityIEP 4763153RGDprotein:increased expression:serum 
IL13 ISOIl13 (Rattus norvegicus)2301686RGD  
IL13 ISOIl13 (Rattus norvegicus)2307110RGDmRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid 
IL13 ISOIl13 (Rattus norvegicus)4145453RGD  
IL13 ISOIl13 (Mus musculus)4145508RGD  
IL13 ISOIl13 (Mus musculus)4145664RGD  
IL13 ISOIl13 (Mus musculus)4206706RGD  
IL13severityISOIl13 (Mus musculus)4145639RGD  
IL13susceptibilityIAGP 7240710OMIM  
IL13 EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:22867017
IL13 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Asthma, susceptibility toPMID:11588017 PMID:11709756 PMID:12847555 PMID:15879126
IL13 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Asthma, susceptibility toPMID:10699178 PMID:12928861 PMID:15356556 PMID:15483090 PMID:15711639
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