GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mtor | decreases expression | EXP | | 6480464 | CTD | Rotenone results in decreased expression of MTOR mRNA | PMID:23186747 | Mtor | multiple interactions | EXP | | 6480464 | CTD | [Particulate Matter co-treated with Rotenone] results in increased expression of MTOR protein; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in increased expression of MTOR protein] | PMID:33823232 | Mtor | decreases expression | ISO | Mtor (Rattus norvegicus) | 6480464 | CTD | Rotenone results in decreased expression of MTOR protein | PMID:28238857 | Mtor | decreases phosphorylation | ISO | Mtor (Rattus norvegicus) | 6480464 | CTD | Rotenone results in decreased phosphorylation of MTOR protein | PMID:29174113 PMID:33137417 PMID:34182063 | Mtor | decreases phosphorylation | ISO | MTOR (Homo sapiens) | 6480464 | CTD | Rotenone results in decreased phosphorylation of MTOR protein | PMID:34182063 | Mtor | increases phosphorylation | ISO | MTOR (Homo sapiens) | 6480464 | CTD | Rotenone results in increased phosphorylation of MTOR protein | PMID:30141137 PMID:31926197 | Mtor | multiple interactions | ISO | Mtor (Rattus norvegicus) | 6480464 | CTD | [asiaticoside co-treated with Rotenone] results in decreased expression of MTOR protein; [Levodopa co-treated with Rotenone] results in increased expression of MTOR protein; [Particulate Matter co-treated with Rotenone] results in increased expression of MTOR protein; [Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; [Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]; ADIPOQ protein promotes the reaction [Rotenone results in decreased phosphorylation of MTOR protein]; CAT protein inhibits the reaction [[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]]; CAT protein inhibits the reaction [[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]]; dorsomorphin inhibits the reaction [ADIPOQ protein promotes the reaction [Rotenone results in decreased phosphorylation of MTOR protein]]; dorsomorphin inhibits the reaction [Rotenone results in decreased phosphorylation of MTOR protein]; FBXO22 protein inhibits the reaction [Rotenone results in decreased phosphorylation of MTOR protein]; GHRL protein inhibits the reaction [Rotenone results in decreased phosphorylation of MTOR protein]; GHSR protein affects the reaction [GHRL protein inhibits the reaction [Rotenone results in decreased phosphorylation of MTOR protein]]; MTOR protein inhibits the reaction [Rotenone results in increased abundance of Hydrogen Peroxide]; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in increased expression of MTOR protein] | PMID:25304210 PMID:28238857 PMID:29174113 PMID:33137417 PMID:33823232 PMID:34182063 | Mtor | multiple interactions | ISO | MTOR (Homo sapiens) | 6480464 | CTD | FBXO22 protein inhibits the reaction [Rotenone results in decreased phosphorylation of MTOR protein]; geraniol inhibits the reaction [Rotenone results in increased phosphorylation of MTOR protein]; PHLPP1 protein affects the reaction [Rotenone results in decreased phosphorylation of MTOR protein]; PHLPP1 protein inhibits the reaction [FBXO22 protein inhibits the reaction [Rotenone results in decreased phosphorylation of MTOR protein]]; polydatin inhibits the reaction [Rotenone results in increased phosphorylation of MTOR protein] | PMID:30141137 PMID:31926197 PMID:34182063 | | ||||||||||||||||||||||
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